324517

4EGI-1

≥98% (sum of two isomers, HPLC), eIF4E inhibitor, solid

• 同義詞: eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
• 經驗公式（希爾表示法）: C₁₈H₁₂Cl₂N₄O₄S
• CAS 編號: 315706-13-9
• 分子量：: 451.28
• MDL號碼: MFCD10565943
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 產品名稱: eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• 品質等級: 100
• 化驗: ≥98% (sum of two isomers, HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+
• InChI 密鑰: KFRKRECSIYXARE-HYARGMPZSA-N

描述

一般說明

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC₅₀ = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

包裝

Packaged under inert gas

準備報告

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Moerke, N. J., et al. 2007. Cell128, 257.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Toxicity: Harmful (C)

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 677.1 °F - (calculated)
• 閃點（°C）: 358.4 °C - (calculated)