400084
HIF Prolyl Hydroxylase Inhibitor
同義詞:
HIF Prolyl Hydroxylase Inhibitor
跳轉至
化驗
≥95% (HPLC)
品質等級
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
tan
溶解度
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
1 of 4
本產品 | 400087 | 400086 | 662086 |
|---|---|---|---|
| form solid | form solid | form solid | form solid |
| assay ≥95% (HPLC) | assay ≥95% (sum of two isomers) | assay ≥90% (HPLC) | assay ≥95% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition OK to freeze | storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light |
一般說明
A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
準備報告
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Toxicity: Standard Handling (A)
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Eva Klumpen et al.
Biology of the cell, 109(1), 39-64 (2016-08-16)
Heat stress in ectotherms involves direct (e.g. protein damage) and/or indirect effects (temperature-induced hypoxia and ROS formation), which cause activation of the transcription factors (TF) heat shock factor 1 (HSF-1) and/or hypoxia-inducible factor 1 (HIF-1). The present study focused on
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