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Merck

559388

SB 202190

≥98% (HPLC), solid, p38 MAP kinase inhibitor, Calbiochem®

同義詞:

SB 202190

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關於此項目

經驗公式（希爾表示法）:
C20H14FN3O
CAS 編號:
152121-30-7
分子量：:
331.34
MDL號碼:
MFCD00941964
分類程式碼代碼:
12352202
NACRES:
NA.77

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產品名稱

SB 202190, SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC50 = 350 nM).

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

效力

16 nM Ki

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

pale yellow

溶解度

DMSO: 50 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

Fc1ccc(cc1)C2=C(NC(=C4C=CC(=O)C=C4)N2)c3ccncc3

InChI

1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H

InChI 密鑰

NJNKPVPFGLGHPA-UHFFFAOYSA-N

相關類別

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本產品
559389S7067559397
SB 202190 SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC50 = 350 nM).

Millipore

559388

SB 202190

SB 203580 SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells).

Sigma-Aldrich

559389

SB 203580

SB 202190 ≥98% (HPLC)

Sigma-Aldrich

S7067

SB 202190

SB 202190 InSolution, ≥98%, p38 MAP kinase inhibitor

Sigma-Aldrich

559397

SB 202190

form

solid

form

film (Thin)

form

powder

form

liquid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

OK to freeze, protect from light

一般說明

一种有效的、可逆的、竞争性的、细胞渗透性p38 MAP激酶抑制剂。抑制髓鞘碱性蛋白（MBP）的p38磷酸化，而不影响ERK或JNK MAP激酶亚群的活性。还抑制p38β的激酶活性（Ki=16 nM；IC50=350 nM）和激活转录因子2的p38磷酸化（ATF-2；IC50=280 nM）。阻断LPS诱导的TNF-α和白细胞介素生物合成已报道在Hep52细胞中诱导LDL受体表达。也可提供SB 202190（目录号559397）在无水DMSO中的1 mg/ml溶液。

生化／生理作用

主要靶标
p38β
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：针对p38β的激酶活性，为350 nM；针对激活转录因子2(ATF-2)的p38磷酸化，为280 nM

準備報告

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他說明

Davies, S.P., et al. 2000.Biochem.J.351, 95.
Ajizian, S.J., et al. 1999.J. Infect.Dis.179, 939.
Singh, R.P., et al. 1999.J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999.Inflamm.Res.48, 533.
Gallagher, T.F., et al. 1997.Bioorg.Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997.Biochem.36, 10422.
Jiang, Y., et al. 1996.J. Biol. Chem. 271, 17920.
Kramer, R.M., et al. 1996.J. Biol. Chem.271, 27723.
Li, Z., et al. 1996.Biochem.Biophys.Res.Commun.228, 334.
Lee, J.C., et al. 1994.Nature 372, 739.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

毒性：标准处理（A）

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

分析證明 (COA)

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