There are two forms of Neuropilin: Neuropilin-1 and Neuropilin-2. These are non–tyrosine kinase receptors that bind to VEGF and semaphorins (SEMA3A, SEMA3B, and SEMA3F) and play an important role in the critical functioning of the nervous system. Neuropilin-2 is expressed in tumor cells, and mature and developing endothelial cells and vascular smooth muscle cells. This expression has been associated with tumor angiogenesis and progression.
免疫原
His-tagged partial recombinant rat Neuropilin-2 protein.
應用
Detect Neuropilin-2 using this Anti-Neuropilin-2 Antibody validated for use in WB, IH, IP & IF.
Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance
Cell replacement therapy is expected as a new and more radical treatment against brain damage. We previously reported that transplanted human cerebral organoids extend their axons along the corticospinal tract in rodent brains. The axons reached the spinal cord but
