AB2204

抗-BMAL1抗体

Name: 抗-BMAL1抗体
Brand: MM

serum, from guinea pig

同義詞:

ARNT-like protein 1, brain and muscle, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, member of PAS protein 3, aryl hydrocarbon receptor nuclear translocator-like, bHLH-PAS protein JAP3, basic-helix-loop-helix-PAS orphan MOP3 2, m

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分類程式碼代碼:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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生物源

guinea pig

品質等級

100

共軛

unconjugated

抗體表格

serum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

mouse, human, rat

技術

western blot: suitable

NCBI登錄號

NP_031515

UniProt登錄號

O00327

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ARNTL(406)
mouse ... Arntl(11865)
rat ... Arntl(29657)

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本產品	ABE2599	MABN673	ABN1386
Sigma-Aldrich AB2204 抗-BMAL1抗体	Sigma-Aldrich ABE2599 Anti-BMAL1	Sigma-Aldrich MABN673 Anti-ARNTL Antibody, clone 1C5	Sigma-Aldrich ABN1386 Anti-HES-1 Antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source guinea pig	biological source guinea pig	biological source mouse	biological source rabbit
antibody form serum	antibody form affinity isolated antibody	antibody form ascites fluid	antibody form affinity isolated antibody
species reactivity mouse, human, rat	species reactivity human, mouse, rat	species reactivity human	species reactivity mouse
shipped in wet ice	shipped in ambient	shipped in wet ice	shipped in dry ice
technique(s) western blot: suitable	technique(s) ChIP: suitable (ChIP-chip), ChIP: suitable (ChIP-seq), immunoprecipitation (IP): suitable	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable

一般說明

~69 kDa

脑和肌肉Arnt样蛋白-1（BMAL1；也称为MOP3或Arnt3）是一种转录因子，已知可调节昼夜节律。BMAL1是哺乳动物生物钟的唯一组成部分，其在小鼠模型中的唯一缺失会产生心律不齐。除了时钟缺陷外，这些BMAL1空小鼠还具有生殖问题，身材矮小，衰老快，并且患有进行性关节病，导致整体运动能力低于野生型小鼠。最近的表型数据表明，BMAL1及其伴侣时钟在调节葡萄糖稳态和代谢中也起作用。最后，BMAL1、NPAS2和PER2与人类季节性情感障碍有关。 BMAL1转录是昼夜节律的，并受NR1D1（Rev-erb-alpha）和RORA的相互调节，后者在哺乳动物昼夜节律时钟中建立了第二个互锁环。

免疫原

表位：C端

重组蛋白

應用

抗BMAL1抗体是用于WB的针对BMAL1的抗体。

研究子类别
昼夜节律 & 睡眠

研究类别
神经科学

生化／生理作用

与其他物种的反应性尚未得到测试。

目录#AB2204将识别BMAL1的C端。

外觀

含0.05% NaN3的血清

準備報告

自收到之日起，在-20°C以未稀释的等分试样可保存1年。

分析報告

对C2C12组织裂解液进行常规检测
批次特定检测应用1：蛋白质印迹法

对照
C2C12组织裂解液

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

分析證明 (COA)

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Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids.

Jeff R Jones et al.

Nature communications, 12(1), 5763-5763 (2021-10-03)

Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone.

The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge.

Karen J Tonsfeldt et al.

Journal of the Endocrine Society, 3(4), 716-733 (2019-03-25)

In rodents, the preovulatory LH surge is temporally gated, but the timing cue is unknown. Estrogen primes neurons in the anteroventral periventricular nucleus (AVPV) to secrete kisspeptin, which potently activates GnRH neurons to release GnRH, eliciting a surge of LH

Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.

Mark A Naven et al.

Theranostics, 12(8), 3963-3976 (2022-06-07)

The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty in obtaining circadian time series human cartilage tissues. As

Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.

LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR

Testing null

Anatomical Methods to Study the Suprachiasmatic Nucleus.

Eric L Bittman

Methods in molecular biology (Clifton, N.J.), 2482, 191-210 (2022-05-25)

The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker. In order to examine mechanisms by which it keeps time, entrains to periodic environmental signals (zeitgebers), and regulates subordinate oscillators elsewhere in the brain and in the periphery, a

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