AB5613P

抗脑源性神经营养因子抗体

Name: 抗脑源性神经营养因子抗体
Brand: MM

Chemicon^®, from rabbit

同義詞:

Prepro-Abrineurin, Pro-Abrineurin, Prepro-BDNF, Pro-BDNF, Prepro-Brain-derived neurotrophic factor, Pro-Brain-derived neurotrophic factor

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分類程式碼代碼:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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生物源

rabbit

品質等級

100

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

mouse, rat, human

製造商／商標名

Chemicon^®

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

NM_001143809
NM_001143810
NM_001709
NM_170731
NM_170734

UniProt登錄號

P23560

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... BDNF(627)

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本產品	AB5613	AB1534SP	AB9042
Sigma-Aldrich AB5613P 抗脑源性神经营养因子抗体	Sigma-Aldrich AB5613 Anti-Brain Derived Neurotrophic Factor Antibody, pro	Sigma-Aldrich AB1534SP 抗脑源性神经营养因子抗体	Sigma-Aldrich AB9042 Anti-Brain Derived Neurotrophic Factor Antibody, pro
antibody form affinity isolated antibody	antibody form serum	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source chicken
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) ELISA: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
Gene Information human ... BDNF(627)	Gene Information human ... BDNF(627)	Gene Information human ... BDNF(627)	Gene Information human ... BDNF(627)

一般說明

脑源性神经营养性因子（UniProt P23560；也称为Abrineurin，BDNF，Neurotrophin）由人的BDNF（也称为BULN2）基因（基因ID 627）编码。BDNF是神经营养因子（也称为神经营养因子）NGF家族的成员，是中枢和外周神经系统中特定神经元亚群的分化和存活所必需的。神经营养因子家族由至少四种蛋白质组成，包括NGF，BDNF，NT3和NT4/5。BDNF通过高亲和细胞表面受体gp145/trkB发出信号来介导其神经营养特性。BDNF最开始是由一个信号肽（a.a.1-18）和前肽（aa19-128）序列产生的，去除该序列会产生成熟的BDNF（a.a.129-247）。

观察值约35 kDa（糖基化前体/前BDNF），约50-65 kDa（糖基化前体/前BDNF二聚体）和约26-28 kDa（非糖基化前体/前BDNF或糖基化前体/前BDNF N末端片段）。由于糖基化和/或二聚化，目标条带似乎大于计算的分子量27.82/28.87/29.82/37.12/31.12 kDa（人前体-BDNF亚型1/2/3/4/5）和25.77/26.82/27.77/35.07/29.06 kDa（人前-BDNF亚型1/2/3/4/5）。某些裂解液可能会出现未表征的条带。

免疫原

对应于人BDNF前肽序列内区域的KLH偶联的线性肽。

表位：前肽。

應用

抗脑源性神经营养因子抗体，pro是用于免疫组化和蛋白质印迹的抗体proBDNF。

研究子类别
神经化学&神经营养因子

神经炎症&疼痛

研究类别
神经科学

蛋白质印迹：1：2,000

免疫组化：1:2,000

最佳工作稀释度必须由最终用户进行确定。

生化／生理作用

该多克隆抗体可检测前体BDNF和前BDNF，以及前体BDNF/前BDNF衍生的含有前肽序列的N末端片段（a.a.19-128），但不检测含前肽序列的成熟BDNF或C末端片段。与其他神经营养因子原无交叉反应。

外觀

从10 mM PBS中进行冻干。用20 μL无菌蒸馏水复溶。

準備報告

在接收之日起，将冻干物料在-20°C下保存长达6个月。复溶后以未稀释状态在-20°C下保存长达 6个月。应避免反复冻/融循环。可添加（1：1）甘油（ACS级或更优级）以获得额外的稳定性。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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ZRB1136

Anti-BDNF Antibody, clone 1I14 ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model.

Kevin K Caldwell et al.

Pharmacology, biochemistry, and behavior, 90(4), 614-624 (2008-06-19)

Prenatal ethanol exposure is associated with an increased incidence of depressive disorders in patient populations. However, the mechanisms that link prenatal ethanol exposure and depression are unknown. Several recent studies have implicated reduced brain-derived neurotrophic factor (BDNF) levels in the

Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling.

April P Neal et al.

Toxicological sciences : an official journal of the Society of Toxicology, 116(1), 249-263 (2010-04-09)

Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter release remains unknown. In the current study, we show that Pb(2+) exposure during

Selective Activation of Striatal NGF-TrkA/p75NTR/MAPK Intracellular Signaling in Rats That Show Suppression of Methamphetamine Intake 30 Days following Drug Abstinence.

Oscar V Torres et al.

The international journal of neuropsychopharmacology, 21(3), 281-290 (2017-11-23)

The continuing epidemic of methamphetamine addiction has prompted research aimed at understanding striatal dysfunctions potentially associated with long-term methamphetamine use. Here, we investigated transcriptional and translational alterations in the expression of neurotrophic factors in the rat striatum at 30 days

Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism?

Marion Rodier et al.

PloS one, 9(3), e92416-e92416 (2014-03-29)

Brain-derived neurotrophic factor (BDNF) through TrkB activation is central for brain functioning. Since the demonstration that plasmin is able to process pro-BDNF to mature BDNF and that these two forms have opposite effects on neuronal survival and plasticity, a particular

Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide.

Hayat Banoujaafar et al.

The European journal of neuroscience, 44(5), 2226-2235 (2016-06-17)

Scientific evidence continues to demonstrate a link between endothelial function and cognition. Besides, several studies have identified a complex interplay between nitric oxide (NO) and brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition. Therefore, this study investigated the

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