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Merck

ABN27

Anti-GRIP-1 Antibody, CT

from rabbit, purified by affinity chromatography

同義詞:

glutamate receptor interacting protein 1, glutamate receptor-interacting protein 1

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關於此項目

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

rat

物種活性(以同源性預測)

mouse (based on 100% sequence homology), human (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

技術

immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

rat ... Grip1(84016)

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1 of 4

本產品
MAB2263AB10529SAB5600106
antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

serum

antibody form

purified immunoglobulin

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable, immunoprecipitation (IP): suitable

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

western blot: suitable

technique(s)

immunohistochemistry: 1:100-1:200, western blot: 1:100-1:200

UniProt accession no.

P97879

UniProt accession no.

P19490

UniProt accession no.

P19491

UniProt accession no.

-

clone

polyclonal

clone

RH95, monoclonal

clone

polyclonal

clone

RM296, monoclonal, recombinant monoclonal

一般說明

Glutamate receptor interacting protein-1 (GRIP-1) is a multi-PDZ domain scaffold protein and a member of the steroid receptor coactivator (SRC) family of proteins. GRIP-1 interacts and maneuvers kinesin heavy chains to dendrites by acting as the power source for AMPA receptors. During initial stages of embryonic development, GRIP-1 is essential for typical cell-matrix interactions.
~121 kDa observed

免疫原

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of rat GRIP-1.

應用

Detect GRIP-1 using this Anti-GRIP-1 Antibody, C-terminus validated for use in WB, IP, IH(P).
Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated GRIP-1 from rat brain cytosol tissue lysate.

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected GRIP-1 in rat brain cells.
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

生化/生理作用

This antibody recognizes GRIP-1 at the C-terminus.

外觀

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

準備報告

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Rat brain cytosol tissue lysate
Evaluated by Western Blot in rat brain cytosol tissue lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected GRIP-1 on 10 µg of rat brain cytosol tissue lysate.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 06-986

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Elisabetta Gerace et al.
Journal of neurochemistry (2020-10-28)
Modifications in the subunit composition of AMPA receptors (AMPARs) have been linked to the transition from physiological to pathological conditions in a number of contexts, including EtOH-induced neurotoxicity. Previous work from our laboratory showed that EtOH withdrawal causes CA1 pyramidal
Rocío Palenzuela et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(41), 9945-9963 (2017-09-15)
The regulated transport of AMPA-type glutamate receptors (AMPARs) to the synaptic membrane is a key mechanism to determine the strength of excitatory synaptic transmission in the brain. In this work, we uncovered a new role for the microtubule-associated protein MAP1B
Manjeet K Rao et al.
The Journal of biological chemistry, 289(51), 35087-35101 (2014-10-22)
Genome-wide studies have revealed that genes commonly have a high density of RNA polymerase II just downstream of the transcription start site. This has raised the possibility that genes are commonly regulated by transcriptional elongation, but this remains largely untested

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