A3262

腺苷-3′,5′-环单磷酸三羟甲基氨基甲烷盐

Name: 腺苷-3′,5′-环单磷酸 三羟甲基氨基甲烷盐
Brand: SIGMA

≥97% (HPLC), synthetic, powder

同義詞:

cAMP, 环磷腺苷

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經驗公式（希爾表示法）:

C₁₀H₁₂N₅O₆P · C₄H₁₁NO₃

CAS 編號:

102029-77-6

分子量：:

450.34

MDL號碼:

MFCD00058346

分類程式碼代碼:

41106305

eCl@ss:

32160414

PubChem物質ID:

329770822

NACRES:

NA.51

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產品名稱

腺苷-3′,5′-环单磷酸三羟甲基氨基甲烷盐, ≥97% (HPLC), powder

生物源

synthetic

化驗

≥97% (HPLC)

形狀

powder

顏色

white

溶解度

H₂O: 100 mg/mL

儲存溫度

−20°C

SMILES 字串

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

InChI 密鑰

CLDDYJFNXTUHIN-MCDZGGTQSA-N

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1 of 4

本產品	A9376	A0386	A9501
Sigma-Aldrich A3262 腺苷-3′,5′-环单磷酸三羟甲基氨基甲烷盐	Sigma-Aldrich A9376 腺苷 2′:3′-循环磷酸钠盐钠盐	Sigma-Aldrich A0386 腺苷-3′-磷酸钠盐	Sigma-Aldrich A9501 腺苷-3′,5′-环单磷酸
biological source synthetic	biological source synthetic (organic)	biological source yeast	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥97% (HPLC)	assay ≥93%	assay ≥98% (HPLC)	assay ≥98.5% (HPLC)
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color -	color -	color white

一般說明

在存在腺苷酸环化酶的存在下，由ATP合成腺苷3′,5′-环一磷酸(cAMP)。 cAMP主要用作免疫化学检测分析中的标记。[1]胞内cAMP水平控制着免疫和炎症功能。细菌感染可触发胞内cAMP产生。[2] cAMP水平升高可调节癌细胞中的促分裂原活化蛋白激酶(MAPK) 。cAMP水平改变与白内障和心血管疾病的发病机理有关。 cAMP水平降低会触发糖尿病中胰岛素分泌受损。[3]

應用

腺苷3′,5′-环一磷酸三盐已被用作人类子宫内膜间质细胞 (hESC) 培养[4]和诱导神经干细胞(iNSC)的培养基补充剂。[5]它已用于pink flamindo（红色 cAMP 指示剂）的光谱表征。[6]

生化／生理作用

环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使，并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示，cAMP/PKA 信号通路可抑制细胞增殖，诱导分化并导致细胞凋亡。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number

0000425160

0000364881

SLCF8554

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腺苷-3′,5′-环单磷酸三羟甲基氨基甲烷盐

≥97% (HPLC), synthetic, powder