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Merck

C3821

柠檬酸-葡萄糖溶液 (ACD)

sterile-filtered

同義詞:

抗凝枸橼酸葡萄糖溶液, 枸橼酸葡萄糖溶液

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關於此項目

CAS 編號:
UNSPSC Code:
12161700
NACRES:
NA.25
MDL number:

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產品名稱

柠檬酸-葡萄糖溶液 (ACD), sterile-filtered

sterility

sterile-filtered

form

liquid

pH

4.5-5.5

storage temp.

2-8°C

Quality Level

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本產品
C4431C7165PHR1000
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

liquid

form

liquid

form

liquid

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

pH

4.5-5.5

pH

5.4-6.7

pH

5.2-5.8

pH

-

sterility

sterile-filtered

sterility

sterile-filtered

sterility

aseptically filled

sterility

-

Application

仅供研究使用。不用于诊断操作。
枸橼酸葡萄糖溶液(ACD)可将血液稀释,用于血液学研究。[1]在小鼠心脏穿刺[2]和人体骨髓分离的采血过程中,还作为抗凝剂。 [3]

Biochem/physiol Actions

可用于全血的抗凝;红细胞存活

General description

枸橼酸葡萄糖溶液(ACD)作为抗凝剂和防腐剂,通常用于血液存储。储存在ACD溶液中时,红细胞的理想保质期为21天。[4]ACD溶液中的红细胞利用葡萄糖,再注入时其生存力会受到影响。[5]

Related product

產品號碼
描述
訂價

存儲類別/等級

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


從最近期的版本中選擇一個:

分析證明 (COA)

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已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study
Secunda R, et al.
Cytotechnology, 67(5), 793-807 (2015)
Mingming Yang et al.
Experimental and therapeutic medicine, 20(2), 1253-1260 (2020-08-09)
The p53 gene is well known as a key tumor suppressor gene; it is vital for hematopoietic stem cell differentiation and growth. In the present study, the change of platelets (PLTs) in p53 knockout mice (p53-/- mice) was investigated. The
The storage of hard-packed red blood cells in citrate-phosphate-dextrose (CPD) and CPD-adenine (CPDA-1)
Beutler E and West C
Blood, 54(1), 280-284 (1979)
Hideki Miyachi et al.
International journal of cardiology, 266, 61-66 (2018-06-12)
Acute thrombosis is a crucial cause of bioresorbable vascular graft (BVG) failure. Bone marrow-derived mononuclear cell (BM-MNC)-seeded BVGs demonstrated high graft patency, however, the effect of seeded BM-MNCs against thrombosis remains to be elucidated. Thus, we evaluated an antithrombotic effect
Comparison of equine platelet function and survival in whole blood collected in acid-citrate-dextrose solution or citrate-phosphate-dextrose-adenine solution
Bozorgmanesh R, et al.
Veterinary Clinical Pathology / American Society For Veterinary Clinical Pathology, 46(2), 262-268 (2017)

Questions

1–10 of 13 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the composition of this citrate-dextrose solution? Is it solution A or B as defined by the US Pharmacopeia?

    1 answer
    1. The composition of the citrate-dextrose solution is as follows:
      1. 22.00 g/L Citric Acid, trisodium salt, dihydrate (C3434)
      2. 7.30 g/L Citric Acid, anhydrous (C0759)
      3. 24.50 g/L D-(+) Glucose (G7528)
      Based on this information, it is likely that the solution is ACD A, which is more commonly used than ACD B as defined by the US Pharmacopeia.

      Helpful?

  4. What is the composition of product C3821, Citrate-dextrose solution (ACD)?

    1 answer
    1. This corresponds to an ACD-A type solution. The composition of this product is as follows:
      1. 22.00 g/L C3434, Citric Acid, trisodium salt, dihydrate
      2. 7.30 g/L C0759, Citric Acid, anhydrous
      3.24.50 g/L G7528, D-(+) Glucose.

      Helpful?

  5. Is the quality of the ACD solution affected if the bottles are left at ambient temperature (20°C in a temperature-controlled facility) for 48 hours, considering that they are typically required to be refrigerated?

    1 answer
    1. The recommended storage temperature for the ACD solution is between 2-8°C. There is no formal data to suggest that the product can be stored outside of this range without affecting its quality. Additionally, the product is capable of being shipped at ambient temperature for a duration of up to 14 days.

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  6. Is product C3821, Acid-Citrate-Dextrose, a concentrate? What ratio of product to whole blood is recommended?

    1 answer
    1. C3821 can be considered a stock solution, and the bottle can be used multiple times. The ratio of ACD or Citrate Dextrose solution can vary from one source to another. A ratio of 1:11 is the more concentrated usage recommended, although dilutions as high as 1:16 are sometimes found in the literature. A good compromise might be a 1:12 dilution.
      Given that there is no preservative in the solution, there is a possibility of contaminating the solution through routine use. Therefore, care should be taken to ensure that the solution does not become contaminated through routine use. The recommended storage temperature is 2-8°C.

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  7. Can it used in prp preparation?

    1 answer
    1. This product is not tested for platelet-rich plasma preparation, however, Acid Citrate-Detrose is commonly used in this procedure. There is no reason to suspect that this item would not be appropriate. This product is intended for research use only and is not suitable for IVD or therapeutic use.

      Helpful?

  8. Hi, I want to order ACD-A solution, I found you have ACD (C3821), I wonder if you can provide the content and concentration of your ACD so that I can compare and see what´s difference between your ACD and ACD-A

    1 answer
    1. This product is equivalent to ACD- A solution.
      The composition is as follows:
      22.00 g/L C3434, Citric Acid, trisodium salt, dihydrate
      7.30 g/L C0759, Citric Acid, anhydrous
      24.50 g/L G7528, D-(+) Glucose (Dextrose)

      Helpful?

  9. HI, I have this product Dextrose solution C3821-10X50ML. How long could I let it at room temps. It was shipped and keeping in shiping for 3 days. Thanks, Chenier

    1 answer
    1. This product is shipped in ambient temperature. Once the product arrives to the address on the order, it is to be stored at 2-8°C by the end-user. Products shipped ambient but stored frozen or refrigerated should be stable in ambient temperature for up to two weeks. Please view this link for more information on Storage and Transport Conditions: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/232/426/storage-transport-conditions-ms.pdf.

      Helpful?

  10. At what concentration should Product C3821, Citrate-dextrose solution, be used?

    1 answer
    1. Use 1 part citrate dextrose solution to 9 parts blood.

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1–10 of 13 Questions  

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