D9175
硝苯呋海因 钠盐
Ca2+ release from sarcoplasmic reticulum inhibitor, solid
同義詞:
1-[[[5-(4-硝基苯)-2-呋喃基]亚甲基氨基]-2,4-咪唑啉二酮 钠盐
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經驗公式（希爾表示法）:
C14H9N4NaO5
CAS 編號:
分子量：:
336.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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產品名稱
硝苯呋海因 钠盐,
形狀
solid
品質等級
起源
JHP Pharmaceuticals
SMILES 字串
[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O
InChI
1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
InChI 密鑰
KSRLIXGNPXAZHD-HAZZGOGXSA-M
基因資訊
human ... RYR1(6261), RYR3(6263)
尋找類似的產品？ 前往 產品比較指南
1 of 4
本產品 | Z2625 | 251680 | P2371 |
|---|---|---|---|
| form solid | form - | form solid | form solid |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| originator JHP Pharmaceuticals | originator - | originator - | originator Novartis |
| Gene Information human ... RYR1(6261), RYR3(6263) | Gene Information - | Gene Information - | Gene Information - |
生化／生理作用
肌浆网 Ca2+ 释放的抑制剂；肌肉松弛剂。
特點和優勢
《受体分类和信号转导》手册的 InsP3/Ryanodine 受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由JHP Pharmaceuticals开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Beth A McNally et al.
Frontiers in physiology, 12, 737291-737291 (2021-10-16)
Daily regulation of Ca2+ - and voltage-activated BK K+ channel activity is required for action potential rhythmicity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the brain's circadian clock. In SCN neurons, BK activation is dependent upon multiple types of
Jiao Liu et al.
Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
Z H Németh et al.
Brain research bulletin, 46(3), 257-261 (1998-07-17)
Recent studies suggested that transmitters released from the sympathetic nerve terminals can modulate various inflammatory responses by occupation of receptors on immune cells. These neurotransmitters act via alteration of intracellular concentration of second messengers. For instance, intracellular calcium as a
Pedro Xavier Royero et al.
Experimental neurology, 327, 113213-113213 (2020-01-29)
Status epilepticus (SE) is a clinical emergency that can lead to the development of temporal lobe epilepsy (TLE). The development and maintenance of spontaneous seizures in TLE are linked to calcium (Ca+2)-dependent processes such as neuronal cell loss and pathological
Mohammed Ali Azam et al.
Heart rhythm O2, 2(6Part B), 733-741 (2022-01-07)
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
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