F1147

Fumonisin B₁

Name: Fumonisin B&#8321;
Brand: SIGMA

From Fusarium sp. (Fusarium moniliforme), ≥98% (HPLC), ceramide synthase (sphingosine N-acetyltransferase) inhibitor, powder

Fumonisin B1 from Fusarium moniliforme

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同義詞:

Macrofusine

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經驗公式（希爾表示法）:

C₃₄H₅₉NO₁₅

CAS 編號:

116355-83-0

分子量：:

721.83

UNSPSC Code:

12352200

PubChem Substance ID:

24894752

NACRES:

NA.32

MDL number:

MFCD27977580

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產品名稱

Fumonisin B₁ 来源于串珠镰刀菌, ≥98% (HPLC)

SMILES string

CCCC[C@@H](C)[C@@H](OC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@@H](CC(O)=O)C(O)=O

InChI

1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1

InChI key

UVBUBMSSQKOIBE-DSLOAKGESA-N

biological source

Fusarium sp. (Fusarium moniliforme)

assay

≥98% (HPLC)

form

powder

solubility

methanol: 9.80-10.20 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

Quality Level

300

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本產品	F3771	SML1286	344850-M
Sigma-Aldrich F1147 Fumonisin B₁ 来源于串珠镰刀菌	Sigma-Aldrich F3771 Fumonisin B₂ from Fusarium moniliforme	Sigma-Aldrich SML1286 Fumonisin B1 Ready Made Solution	Millipore 344850-M Fumonisin B₁, Fusarium moniliforme
assay ≥98% (HPLC)	assay ≥96% (TLC)	assay -	assay ≥95% (TLC)
biological source Fusarium sp. (Fusarium moniliforme)	biological source Fusarium sp. (Fusarium moniliforme)	biological source (Fusarium moniliforme)	biological source -
Quality Level 300	Quality Level 100	Quality Level 200	Quality Level 100
form powder	form powder	form DMSO solution	form powder
solubility methanol: 9.80-10.20 mg/mL, clear, colorless to light yellow	solubility methanol: 10 mg/mL, clear, colorless to faintly yellow	solubility -	solubility methanol: 5 mg/mL
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

Application

来自霉菌镰刀菌的伏马菌素B1已被用于：

对从成年猪盲肠内容物中的真菌毒素进行分析的标准品
研究伏马菌素B1对朊病毒蛋白（PrP）异构体的代谢和羊瘙痒病朊病毒蛋白PrP^Sc合成的影响，以及
研究伏马毒素B1对猪空肠外植体的毒性作用。[1][2][3]

Biochem/physiol Actions

伏马菌素B1可作为肝致癌物，并在大鼠中引起肝毒性。它在马中会引起白脑脑炎，而在猪中会引起肺水肿综合征。在中国和非洲南部地区，它与人类食道癌的高发有关。它可充当鞘氨醇N-酰基转移酶（神经酰胺合成酶）的抑制剂，[4]这与伏马菌素B1和鞘氨醇碱基（如鞘氨醇）之间的结构相似性有关。

真菌代谢物据信可引起马脑白质软化症。

General description

伏马菌素B1是一种霉菌毒素，存在于许多镰刀菌真菌，例如串珠镰刀菌、层出镰孢菌和拟轮生镰刀菌。这种毒素也存在于被镰刀菌感染的原料和食品，例如玉米。

伏马菌素B1（FB1）与鞘氨醇结构相似。因此，伏马菌素B1可以抑制神经酰胺合成酶（鞘氨醇N-乙酰基转移酶），其可导致神经酰胺生物合成和复杂鞘脂生物合成的中断。[4]

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351,H361d,H373

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Kidney,Liver

存儲類別/等級

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析證明 (COA)

Lot/Batch Number

0000484224

0000463729

0000463709

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Inhibition of Protein Serine/Threonine Phosphatases by Fumonisin B1, a Mycotoxin.

Fukuda H

Biochemical and Biophysical Research Communications, 220, 160-165 (1996)

In vitro microbial metabolism of fumonisin B1.

Judit Fodor et al.

Food additives and contaminants, 24(4), 416-420 (2007-04-25)

There is a lack of information on the effect of swine caecal microbiota on fumonisin metabolism. In this in vitro study, the biotransformation of fumonisin B(1) (FB(1)) by the gut microbiota of adult, healthy pigs was examined. Suspensions of caecal

Deoxynivanelol and fumonisin, alone or in combination, induce changes on intestinal junction complexes and in E-cadherin expression.

Karina Basso et al.

Toxins, 5(12), 2341-2352 (2013-11-30)

Fusariotoxins such as fumonisin B1 (FB1) and deoxynivalenol (DON) cause deleterious effects on the intestine of pigs. The aim of this study was to evaluate the effect of these mycotoxins, alone and in combination, on jejunal explants from piglets, using

Visualisation and quantification of fumonisins bound by lactic acid bacteria isolates from traditional African maize-based fermented cereals, ogi and mahewu.

Pranitha Dawlal et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(2), 296-307 (2019-01-25)

Consumption of fumonisin-contaminated foods has a negative influence on the health of humans (carcinogen; oesophageal cancer in Eastern Cape in South Africa). Lactic acid bacteria (LAB) have emerged as a promising natural detoxification agent against mycotoxins. The aim of this

A rapid method for detection of fumonisins B1 and B2 in corn meal using Fourier transform near infrared (FT-NIR) spectroscopy implemented with integrating sphere.

B Gaspardo et al.

Food chemistry, 135(3), 1608-1612 (2012-09-08)

Fourier transform near infrared (FT-NIR) spectroscopy is an analytical procedure generally used to detect organic compounds in food. In this work the ability to predict fumonisin B(1)+B(2) contents in corn meal using an FT-NIR spectrophotometer, equipped with an integration sphere

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