Stock solutions should be made in pure, anhydrous DMSO.
P8139
佛波醇12-十四酸酯13-乙酸酯
≥99% (TLC), film or powder, PKC activator
Phorbol 12-myristate 13-acetate
同義詞:
12-O-十四烷酰基佛波醇13-乙酸酯, 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯, PMA, TPA
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經驗公式（希爾表示法）:
C36H56O8
CAS 編號:
分子量：:
616.83
Beilstein:
2407201
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77
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產品名稱
佛波醇12-十四酸酯13-乙酸酯, ≥99% (TLC), film or powder
品質等級
化驗
≥99% (TLC)
形狀
film or powder
溶解度
DMSO: soluble
ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)
儲存溫度
−20°C
SMILES 字串
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
InChI
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChI 密鑰
PHEDXBVPIONUQT-RGYGYFBISA-N
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相關類別
1 of 4
本產品 | 79346 | 19-144 | P1585 |
|---|---|---|---|
| form film or powder | form film | form solid | form (Lyophilisate) |
| assay ≥99% (TLC) | assay ≥98.0% (TLC) | assay - | assay ≥99% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. −20°C |
| solubility DMSO: soluble, ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.) | solubility chloroform: 10 mg/mL, clear, colorless to light yellow | solubility - | solubility DMSO: soluble (DMSO solutions can be stored dark at −20 °C for at least six months.), ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions) |
一般說明
12-肉豆蔻酸-13-乙酸佛波醇酯(PMA)具有较强的抗炎作用。可激活蛋白激酶C(PKC)活性。PMA可诱导蛋白酶、细胞因子和NADPH氧化酶的释放，导致组织损伤或组胺生成，促进血管重塑、发红、发热和促肿瘤作用。此外，还增强活性氧(ROS)产生，减少参与ROS解毒的酶。PMA还抑制超氧化物歧化酶(SOD)、过氧化氢酶和谷胱甘肽过氧化物酶的基础水平。[1]
佛波醇12-肉豆蔻酸酯13-乙酸酯是一种佛波酯。它可作为肿瘤促进因子并通过蛋白激酶C（PKC）信号通路参与基因转录、细胞生长、分化、程序性细胞死亡、免疫途径和受体脱敏。佛波醇12-肉豆蔻酸酯13-乙酸酯还是一种研究生长因子、激素和细胞因子介导的细胞生长和分化调控的模范试剂。[2]
先溶于与水混溶的有机溶剂，再配制水溶液。DMSO溶液可在-20 °C避光储存至少6个月。
應用
其他說明
免責聲明
光敏感的
訊號詞
Danger
危險分類
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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Toomey JA et al.
Journal of Leukocyte Biology, 74, 233-233 (2003)
Arginine and glutamine supplementation to culture media improves the performance of various channel catfish immune cells
Pohlenz C, et al.
Journal of Separation Science, 32(5), 762-768 (2012)
Inhibition of protein kinase C results in decreased expression of bovine leukemia virus.
Jensen WA et al.
Journal of Virology, 66, 4427-4427 (1992)
Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1 alpha-NF-kappa B Crosstalk In Vitro and In Vivo
Chang SN, et al.
International Journal of Molecular Sciences (2020)
NGFI-A gene expression is necessary for T lymphocyte proliferation.
Perez-Castillo A et al.
The Journal of Biological Chemistry, 268, 19445-19445 (1993)
文章
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
相關內容
Product Information Sheet
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When making up the 20mM solution of PMA, what percentage/molarity of DMSO should be within this solution? Is the solution in water + DMSO?
1 answer-
Helpful?
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Hello, do you have any information on the stability of this product with regard to freeze/thaw after it is reconstituted? We normally thaw our aliquot, take what we need, and then refreeze our aliquots.
1 answer-
Freeze/thaw cycles are not recommended for this product.
Helpful?
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Do you have any application information for Product P8139, Phorbol 12-myristate 13-acetate?
1 answer-
View the P8139 product information sheet (under Documents, above).
Helpful?
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How should Product P8139, Phorbol 12-myristate 13-acetatebe dissolved?
1 answer-
Stock solutions of 20 mM can be prepared in DMSO and diluted into aqueous buffers. View more information on P8139 solubility in the product information sheet (under Documents, above).
Helpful?
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What is the difference between Phorbol 12-myristate 13-acetate, Product P8139 and molecular biology grade Product P1585?
1 answer-
Product P1585 has been tested and found suitable for stimulation of interleukin 2 production of Jurkat cells. Product P8139 has not tested in this application.
Helpful?
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Why do I not see any solid in the Phorbol 12-myristate 13-acetate bottle, Product P8139?
1 answer-
Phorbol 12-myristate 13-acetate may be an invisible film in the bottle.
Helpful?
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How should I store the solutions of Product P8139, Phorbol 12-myristate 13-acetate?
1 answer-
Stock solutions in DMSO can be stored protected from light as aliquots at -20°C for at least 6 months, or at 2-8°C for up to 3 months.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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