SML0148

Imidapril hydrochloride

≥98% (HPLC)

• 同義詞: (4S)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride, Novaloc, TA 6366, Tanapril
• 經驗公式（希爾表示法）: C₂₀H₂₇N₃O₆ · HCl
• CAS 編號: 89396-94-1
• 分子量：: 441.91
• MDL號碼: MFCD00923828
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825196
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D -50 to -70° in ethanol (c=0.5)
• 顏色: white to tan
• 溶解度: H₂O: ≥5 mg/mL
• 起源: Trinity Pharma Solutions
• 儲存溫度: −20°C
• SMILES 字串: Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@@H](CN(C)C2=O)C(O)=O
• InChI: 1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
• InChI 密鑰: LSLQGMMMRMDXHN-GEUPQXMHSA-N

描述

一般說明

Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.[1]

應用

Imidapril hydrochloride may be used to test its effect on pharyngeal and laryngeal muscle to treat impaired swallowing.[2]

Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.[3]

生化／生理作用

Angiotensin Converting Enzyme (ACE) inhibitor

Imidapril hydrochloride is a long-acting inhibitor of angiotensin converting enzyme used in the treatment of hypertension, congestive heart failure and diabetic nephropathy.[4] It restores decreased airway sensation and bladder sensation in patients with multiple sclerosis.[4][5]

Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.

特點和優勢

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Trinity Pharma Solutions. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable