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Merck

Z4775

嘧啶酮-B-核甙

≥98% (HPLC), cytidine analogue, solid

同義詞:

1-（β-D-呋喃核糖基）-1,2-二氢嘧啶-2-酮, 2-嘧啶酮-1-β- D -核苷

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關於此項目

經驗公式（希爾表示法）:
C9H12N2O5
CAS 編號:
3690-10-6
分子量：:
228.20
UNSPSC Code:
12352203
PubChem Substance ID:
329831617
NACRES:
NA.77
MDL number:
MFCD04973699

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產品名稱

嘧啶酮-B-核甙, ≥98% (HPLC), solid

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC=NC2=O

InChI

1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1

InChI key

RPQZTTQVRYEKCR-WCTZXXKLSA-N

assay

≥98% (HPLC)

form

solid

solubility

DMSO: 16 mg/mL

storage temp.

2-8°C

Quality Level

100

相關類別

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本產品
691400D8296SML2310
嘧啶酮-B-核甙 ≥98% (HPLC), solid

Sigma-Aldrich

Z4775

嘧啶酮-B-核甙

嘧啶酮-B-核甙 A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Sigma-Aldrich

691400

嘧啶酮-B-核甙

3-Deazaadenosine

Sigma-Aldrich

D8296

3-Deazaadenosine

Thiodigalactoside ≥98% (HPLC)

Sigma-Aldrich

SML2310

Thiodigalactoside

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

-

assay

≥98% (HPLC)

form

solid

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 16 mg/mL

solubility

DMSO: 5 mg/mL, methanol: 5 mg/mL

solubility

-

solubility

H2O: 2 mg/mL, clear

Biochem/physiol Actions

Zebularine 是一种胞苷类似物，胞苷脱氨酶抑制剂和 DNA 去甲基化剂。

Features and Benefits

该化合物是基因调控研究的特色产品。点击此处，发现更多特色基因调控产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。

存儲類別/等級

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000233911
0000233911
0000182000
0000156430

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Li Chen et al.
Frontiers in genetics, 9, 254-254 (2018-08-02)
Large-scale tumor genome sequencing projects have revealed a complex landscape of genomic mutations in multiple cancer types. A major goal of these projects is to characterize somatic mutations and discover cancer drivers, thereby providing important clues to uncover diagnostic or
Yukitoshi Takemura et al.
Bioscience, biotechnology, and biochemistry, 82(7), 1159-1164 (2018-04-25)
Malignant mesothelioma is an asbestos-related aggressive tumor and current therapy remains ineffective. Zebularine as a DNA methyltransferase (DNMT) inhibitor has an anti-tumor effect in several human cancer cells. The aim of the present study was to investigate whether zebularine could
Takashi Akagi et al.
The Plant cell, 28(12), 2905-2915 (2016-12-14)
Epigenetic regulation can add a flexible layer to genetic variation, potentially enabling long-term but reversible cis-regulatory changes to an allele while maintaining its DNA sequence. Here, we present a case in which alternative epigenetic states lead to reversible sex determination
Victor E Marquez et al.
Annals of the New York Academy of Sciences, 1058, 246-254 (2006-01-06)
1-(Beta-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine) corresponds structurally to cytidine minus the exocyclic 4-amino group. The increased electrophilic character of its simple aglycon endows the molecule with unique biologic properties as a potent inhibitor of both cytidine deaminase and DNA cytosine methyltransferase. The latter
C B Yoo et al.
Biochemical Society transactions, 32(Pt 6), 910-912 (2004-10-28)
Regulatory genes are often hypermethylated at their promoter 5' regions and silenced in cancer. Epigenetic therapy with DNA methylation inhibitors have been shown to result in the demethylation and reactivation of these genes. Zebularine is a recently discovered mechanism-based inhibitor
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