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  • Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones.

Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones.

European journal of medicinal chemistry (2009-08-12)
Tanvir Hussain, Hamid Latif Siddiqui, Muhammad Zia-ur-Rehman, Muhammad Masoom Yasinzai, Masood Parvez
ABSTRACT

A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Propyl gallate, powder
Sigma-Aldrich
Propyl gallate, antioxidant, ≥98.0% (HPLC)
Sigma-Aldrich
Propyl gallate, ≥98%, FCC
Sigma-Aldrich
4-(1H-Imidazol-1-yl)benzaldehyde, 98%