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  • Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.

Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.

Chemical & pharmaceutical bulletin (2001-01-06)
T Nishiyama, Y Ono, S Kurokawa, S Kimura
ABSTRACT

The direct alpha-bromination of various ketones using trifluoromethanesulfonic anhydride and Grignard reagent or magnesium bromide in ether gave the corresponding alpha-bromo ketones in moderate to good yields under mild reaction conditions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethylmagnesium bromide solution, 3.4 M in 2-methyltetrahydrofuran
Sigma-Aldrich
Ethylmagnesium bromide solution, 3.0 M in diethyl ether
Sigma-Aldrich
Ethylmagnesium bromide solution, 1.0 M in THF
Sigma-Aldrich
Ethylmagnesium bromide solution, 1.0 M in tert-butyl methyl ether
Sigma-Aldrich
Ethylmagnesium bromide solution, 40% in 2-methyltetrahydrofuran