Partition coefficients for varied compounds were determined for the organic solvent-propylene carbonate biphasic partition system where the organic solvent is n-heptane, isopentyl ether or 1-octanol. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of the propylene carbonate-based partition systems with other totally organic partition systems. Propylene carbonate is a weak to intermediate cohesive solvent, reasonably dipolar/polarizable and hydrogen-bond basic, and weak hydrogen-bond acidic. Propylene carbonate-organic solvent systems offer a complementary approach to other totally organic biphasic partition systems for sample preparation and descriptor measurements of compounds virtually insoluble or unstable in water.
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