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  • Effect of L-propargylglycine on metabolism of sulfur-containing amino acids in pregnant rats and their fetuses.

Effect of L-propargylglycine on metabolism of sulfur-containing amino acids in pregnant rats and their fetuses.

Biochemistry international (1985-02-01)
K Sasaki, S Awata, H Kodama
ABSTRACT

Cystathionine accumulated in several tissues of dams and fetuses by a single intraperitoneal administration of L-proparglyglycine to pregnant rats. Cystathionine in the liver of dams reached its maximal level at about 15 hrs after L-proparglyglycine injection (10 mg/300g), while that in the kidney and brain of dams, and in the liver, kidney, and brain of fetuses reached a maximum at about 21 hrs. The content of cystine in the liver of fetuses decreased gradually in proportion to the amount of L-proparglyglycine administered. Cystathionine gamma-lyase activity in the liver of dams and fetuses decreased to about 2-4% of that of control rats at 15 hrs after L-proparglyglycine injection, and that in the kidney and pancreas of dams to about 10-20% of that of control rats. On the other hand, cystathionine beta-synthase activity did not show significant changes from that of control rats.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-C-Propargylglycine, ≥99.0% (TLC)