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  • Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

Organic letters (2013-09-03)
Dong Bo Li, Mark Rogers-Evans, Erick M Carreira
ABSTRACT

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Oxytocin acetate salt hydrate, ≥97% (HPLC)
Oxytocin, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Oxytocin, lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)
Sigma-Aldrich
Oxytocin