MilliporeSigma

The role of iron in brain ageing and neurodegenerative disorders.

The Lancet. Neurology (2014-09-19)
Roberta J Ward, Fabio A Zucca, Jeff H Duyn, Robert R Crichton, Luigi Zecca
ABSTRACT

In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in iron homoeostasis result in altered cellular iron distribution and accumulation. MRI can often identify these changes, thus providing a potential diagnostic biomarker of neurodegenerative diseases. An important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iron, granular, 10-40 mesh, >99.99% trace metals basis
Sigma-Aldrich
Iron, foil, thickness 0.25 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Iron, ≥99%, reduced, powder (fine)
Sigma-Aldrich
Carbonyl iron, ≥97% Fe basis
Sigma-Aldrich
Iron, wire, diam. 1.0 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, powder, <10 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, wire, diam. 1.0 mm, ≥99.99% trace metals basis
Iron, wire reel, 10m, diameter 0.5mm, as drawn, 99.95%
Iron, tube, 500mm, outside diameter 10.0mm, inside diameter 7mm, wall thickness 1.5mm, annealed, 99.5%
Iron, tube, 100mm, outside diameter 2.0mm, inside diameter 1.08mm, wall thickness 0.46mm, as drawn, 99.5%
Iron, tube, 100mm, outside diameter 25.0mm, inside diameter 21mm, wall thickness 2mm, annealed, 99.5%
Iron, foil, 50x50mm, thickness 0.38mm, hard, 99.5%
Iron, tube, 1000mm, outside diameter 4.0mm, inside diameter 3.6mm, wall thickness 0.2mm, as drawn, 99.5%
Iron, foil, 10mm disks, thickness 0.004mm, 99.85%
Iron, foil, 50x50mm, thickness 2.0mm, as rolled, 99.95%
Iron, tube, 100mm, outside diameter 9.5mm, inside diameter 8.5mm, wall thickness 0.5mm, as drawn, 99.8+%
Iron, foil, 300x300mm, thickness 3.0mm, as rolled, 99.5%
Iron, wire reel, 2m, diameter 0.25mm, hard, 99.99+%
Iron, wire reel, 2000m, diameter 0.25mm, hard, 99.5%
Iron, foil, 50x50mm, thickness 0.5mm, as rolled, 99.99+%
Iron, wire reel, 2m, diameter 0.5mm, hard, 99.99+%
Iron, wire reel, 1m, diameter 0.13mm, hard, 99.99+%
Iron, wire reel, 0.2m, diameter 1.0mm, as drawn, 99.99+%
Iron, wire reel, 50m, diameter 0.065mm, hard, 99.5%
Iron, tube, 200mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%
Iron, tube, 100mm, outside diameter 2.30mm, inside diameter 2.07mm, wall thickness 0.115mm, as drawn, 99.5%
Iron, foil, 0.2m coil, thickness 0.5mm, coil width 49mm, armco« soft ingot 99.8+%
Iron, tube, 100mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%
Iron, foil, 10m coil, thickness 0.15mm, hard, 99.5%
Iron, tube, 200mm, outside diameter 2.0mm, inside diameter 1.08mm, wall thickness 0.46mm, as drawn, 99.5%