MilliporeSigma
  • Home
  • Search Results
  • Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

International journal of pharmaceutics (2014-05-23)
Maria Grazia Sarpietro, Maria Lorena Accolla, Giovanni Puglisi, Francesco Castelli, Lucia Montenegro
ABSTRACT

In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Palmityl palmitate, ≥99%
Cetyl palmitate 95, European Pharmacopoeia (EP) Reference Standard
Supelco
Diethyl ether, analytical standard
Sigma-Aldrich
Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
Supelco
Cetyl Palmitate, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Zirconyl chloride octahydrate, reagent grade, 98%
Cetyl palmitate 15, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Diethyl ether, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor
Sigma-Aldrich
Diethyl ether, contains BHT as inhibitor, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%
Sigma-Aldrich
Diethyl ether, puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)
Sigma-Aldrich
Diethyl ether, reagent grade, ≥98%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor
Sigma-Aldrich
Diethyl ether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor
Sigma-Aldrich
Diethyl ether, suitable for HPLC, ≥99.9%, inhibitor-free
Sigma-Aldrich
Diethyl ether, ACS reagent, ≥98.0%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor