RANKL-induced M1 macrophages are involved in bone formation.

Bone research (2017-12-22)
Rong Huang, Xin Wang, Yinghong Zhou, Yin Xiao

The activation of M1 macrophages can be achieved by stimulating them with lipopolysaccharide (LPS) and interferon-γ (IFN-γ). However, M1 can be found under physiological conditions without any pathological stimuli. This study aimed to understand the involvement of RANKL-induced M1 macrophages in bone formation compared with pathologically induced macrophages. Fischer rats were used to investigate macrophage distribution in normal and injured femoral condyles

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Lipopolysaccharides from Escherichia coli O111:B4, purified by gel-filtration chromatography