Important Notice for All Products Marked Department of Agriculture

Download the Department of Agriculture Notice (PDF)

ATTENTION: This information is for all products with a blue Department of Agriculture sticker attached.

All End Users,

Biological products are regulated for import by the Department of Agriculture - Biosecurity (formally AQIS), and as such require permits for their import. All permits are issued with post barrier conditions, which cover specific applications and limitations together with handling and disposal requirements.

In order to comply with the Department of Agriculture requirements for the supply and use of these materials, please take the time to review the following conditions before opening and using the product and also share this information with fellow colleagues who will be using the product.

Department of Agriculture marked products must comply with the following usage conditions:

  1. In-vitro studies and/or in-vivo use in laboratory organisms – Work must be limited to in-vitro laboratory studies or in-vivo use in laboratory organisms only. Laboratory organisms include those defined in the following list and must be contained under laboratory or animal house conditions (or equivalent): guinea pigs, hamsters, mice, rabbits, rats, rodents or micro-organisms.

  2. Non-laboratory animals and plants – For in-vivo use in non-laboratory organisms (e.g. chickens, sheep, cattle, etc. or plants, a separate in-vivo application must be lodged with and approved by the Department of Agriculture.

    Veterinary manufacture – Products for use in veterinary vaccine or veterinary therapeutic manufacture also require Department of Agriculture written approval prior to use. Refer to for details.

  3. Agricultural, environmental or other veterinary applications – In addition, biological products cannot be used in the formulation or manufacture of agricultural, environmental or veterinary products (i.e. pet, stock or fish feeds), fertilisers or bioremediation agents without receiving Department of Agriculture written approval. This approval is also required to use biologicals in aquaculture, fisheries or for bait purposes.

  4. Selective/differential media – The following listed products can ONLY be used for the selective and differential growth of specific microorganisms in in-vitro laboratory applications. All other applications are prohibited.
Product No. Description
07012 M-FC Agar
13005 Sulfate API Agar
78052 Phenylalanine Agar
79332 Davis Minimal Agar
86558 Buffered Charcoal Yeast Extract Agar
91015 Tributyrin Agar
B8291 BSK-H Medium, Complete, With 6% Rabbit Serum
C4478 S-GAL®/LB Agar Blend, Reagent
L2025 Luria Agar Base, Miller
L2897 LB Agar
L3027 LB Agar, Miller Microbiologically Tested
L3147 Luria Agar
L3272 Luria Agar (Miller's Modification)
L7025 LB Agar Tablets to Make 50 ml
L7533 EZMix™ LB Agar
M0660 Mycoplasma Agar Microbiologically Tested
M6907 Malt Extract Agar
S1813 S-GAL® Kanamycin/LB Agar Blend
S9938 S-GAL®/LB Agar Blend, Without IPTG
  1. Microbiological culture or viral isolation applications – We recommend if you are using any Department of Agriculture labelled product in viral isolation studies or microbiological cultures that you call the Sigma-Aldrich Compliance team on 1800 800 097. They will be able to advise you if a separate Department of Agriculture approval is required for your specific product number.

    Application forms to use your product in microbiological culture or viral isolation are also located at:

    The following list provides examples of product categories that must have written approval from Department of Agriculture for use in viral isolation and/or microbiological cultures. Please note this list is not comprehensive.
  • Adjuvants (i.e. Freund’s and Sigma® Adjuvant system)
  • Amino acids derived from animal products (i.e. L-Cystine, N-Acetyl-L-Cysteine)
  • Antibiotics (fermented or containing animal material)
  • Antibodies
  • Antisera
  • Bile acids & derivatives (B8756, C1129, C1254, C6445, D4297, D6750, G7132, L6250, T0557, T0875, T4009, T7515, T9034, 19899, 10810118001 & all CHAPS
  • Carbohydrates (inc. polysaccharides, cyclic oligosaccharides)
  • Cell lines and genetically modified cell lines (from human, primates, rodents, rabbits, insects, amphibians, reptiles, salmonid, non-salmonid finfish species and hybridomas of these species)
  • Cell lysing reagents
  • Chitin, chitosan and their derivatives
  • Citric acid (and all salts)
  • Coenzymes and/or cofactors
  • Collagen solutions (bovine)
  • Detergents, emulsifiers, surfactants (i.e. TWEEN®, Brij®, SDS, Saponin etc)
  • Diagnostic/molecular biology kits (and contents) all brands
  • DNA/cDNA or RNA purified from multicellular organisms
  • Enzymes (inc. modifying, restriction enzymes and polmerases)
  • Enzyme inhibitors
  • Fish extracts (inc. glucosamine, glycogen, pituitary acetone powder, protamine sulfate and oils)
  • Fatty acid supplement (F7050)
  • Gangliosides
  • Gelatines (from bovine, porcine and fish)
  • GeneIOS Reagent Pack
  • Genetic & molecular biology materials
    • Expression vectors
    • Glycerol bacterial stock (SHCLNG)
    • Lentiviral transduction particles eg shRNA, CRISPR
    • Bacterial plasmids and DNA inserts of synthetic origin
    • Zinc finger nucleases (ZFN) & CRISPR/Cas9
  • Growth factors (animal, bacterial, recombinant)
  • Hide powder (bovine)
  • Hormones (animal or recombinant)
  • Human serum/plasma (all pack sizes)
  • Hydridization Buffer (# 11717472001)
  • Ionophores
  • JumpStartTM Taq DNA
  • Lipids (animal, bacterial or recombinant)
  • Lipopolysaccharides
  • Micrococcus lysodeikticus (syn Micrococcus luteus)
  • Mucopolysaccharides (glycoaminoglycans)
  • Nucleosides, nucleotides and/or nucleic acids
  • Peptides (recombinant, animal or bacterial derived)
  • Peptides (conjugated with biological material)
  • Polyethylene glycols (PEG) (that utilise microorganisms in the production)
  • Proteins (animal, bacterial or recombinant)
  • Purines and/or pyrimidines
  • Rabbit serum (all pack sizes)
  • Reference standards containing L-glutamine
  • Saponins
  • Sera, blood, fluids and/or tissues (derived from cattle, chickens, deer, goats, sheep, horses, pigs, rats, mice in pack sizes 20ml or less)
  • Slides containing fixed tissues or cells
  • Sphingolipids
  • Toxins and/or mycotoxins
  • Universal antibody dilution buffer (U3510/U3635)
  • Uric acid (U2625)
  • Venoms
  • Vitamins
  1. In-Vitro Laboratories Studies Only - Some products are only permitted for in-vitro use only. Hence they are prohibited for in-vivo work in all animals (including laboratory animals) and plants. Written approval must be obtained from the Department of Agriculture for in-vivo use.

    These products include but are not limited to:

    • Zinc Finger Nucleases (ZFNs)
    • Kit components in all diagnostic, molecular, GeneIOS and HybriScan kits
    • N-Acetyl-L-Cysteine (A7250, A9165)
    • Cysine and isomers (C2526, C8005, C8755)
    • CP chromoselect agar (12398)
    • CRISPR/Cas Systems
    • Uric acid (U2625)
    • All selective and differential media as listed under Number 4
  2. Direct or indirect exposure of the imported materials or derivatives to non-laboratory organisms or plants is not permitted.

  3. It is the end user’s responsibility to ensure that all laboratory products are used in accordance with the current AS/NZS 2243 Safety in Laboratory standards and Office of Gene Technology Regulator (OGTR) requirements.

If you require further assistance or clarification, please contact the Sigma-Aldrich Compliance team on, 1800 800 097 or

Note: The Department of Agriculture regulated products are also identified on the pack slip which accompanies your consignment. For products transported on dry or wet ice, the Department of Agriculture sticker is attached to the Esky used to transport the product.