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49920

Glycerol formal

≥98.0% (GC)

Synonym(s):

1,3(or 2,3)-O-Methylene-1,2,3-propanetriol

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100 mL

Available to ship TODAY

$78.70
500 mL

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$261.00

About This Item

Empirical Formula (Hill Notation):
C4H8O3
CAS Number:
Molecular Weight:
104.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
103206
Assay:
≥98.0% (GC)

$78.70


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Quality Segment

assay

≥98.0% (GC)

contains

~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

composition

5-hydroxy-1,3-dioxane, ~60% , 4-hydroxymethyl-1,3-dioxolane, ~40%

refractive index

n20/D 1.451

bp

192-193 °C (lit.)

density

1.203 g/mL at 25 °C (lit.)

functional group

ether, hydroxyl

SMILES string

OCC1COCO1.OC2COCOC2

InChI

1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2

InChI key

JIUMSISXCKWZTA-UHFFFAOYSA-N

General description

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Application

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery
Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

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G62794976715523
description

≥98.0% (GC)

description

BioXtra, ≥99% (GC)

description

BioUltra, Molecular Biology, anhydrous, ≥99.5% (GC)

description

puriss., anhydrous, 99.0-101.0% (alkalimetric)

assay

≥98.0% (GC)

assay

≥99% (GC)

assay

≥99.5% (GC)

assay

99.0-101.0% (calc. on H2O free substance), 99.0-101.0% (alkalimetric)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

density

1.203 g/mL at 25 °C (lit.)

density

1.25 g/mL (lit.)

density

1.25 g/mL (lit.)

density

≥1.257 g/mL at 25 °C, 1.2580-1.2644 g/mL at 20 °C, 1.25 g/mL (lit.)

refractive index

n20/D 1.451

refractive index

n20/D 1.474 (lit.)

refractive index

n20/D 1.474

refractive index

n20/D 1.474 (lit.), n20/D 1.470-1.475

bp

192-193 °C (lit.)

bp

182 °C/20 mmHg (lit.)

bp

182 °C/20 mmHg (lit.)

bp

182 °C/20 mmHg (lit.)

contains

~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

contains

-

contains

-

contains

-


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WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Storage Class

10 - Combustible liquids

Flash Point (°F)

199.4 °F - closed cup

Flash Point (°C)

93 °C - closed cup



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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