P0018

Pomalidomide

≥98% (HPLC), powder, HbF inducer

• Synonym(s): 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3
• Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₄
• CAS Number: 19171-19-8
• Molecular Weight: 273.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819974
• NACRES: NA.77
• MDL number: MFCD12756407
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Pomalidomide, ≥98% (HPLC)
• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• reaction suitability: reagent type: ligand
• technique(s): targeted protein degradation: suitable
• color: yellow
• solubility: DMSO: ≥14 mg/mL
• storage temp.: 2-8°C
• SMILES string: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
• InChI key: UVSMNLNDYGZFPF-UHFFFAOYSA-N
• Gene Information: human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Description

Application

Pomalidomide has been used:

• to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
• for apoptosis studies and intracellular calcium analysis
• as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Biochem/physiol Actions

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H360D
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable