P3246

Pipamperone dihydrochloride

~99% (HPLC), dopamine receptor antagonist, powder

• Synonym(s): 1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050
• Empirical Formula (Hill Notation): C₂₁H₃₀N₃O₂F · 2HCl
• CAS Number: 2448-68-2
• Molecular Weight: 448.40
• NACRES: NA.77
• PubChem Substance ID: 24724576
• UNSPSC Code: 12352200
• EC Number: 219-507-5
• MDL number: MFCD00242980
• eCl@ss: 32150313
• Assay: ~99% (HPLC)
• Form: powder

Properties

• Product Name: Pipamperone dihydrochloride, ~99% (HPLC), powder
• assay: ~99% (HPLC)
• Quality Segment: 100
• form: powder
• color: white
• solubility: H₂O: >2.0 mg/mL
• originator: Johnson & Johnson
• SMILES string: Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
• InChI: 1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
• InChI key: BMXXSXQVMCXGJM-UHFFFAOYSA-N

Description

Application

Pipamperone dihydrochloride may be used:

• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.

D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• WGK: WGK 1
• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves