This product is soluble in ethanol and oils. Deleted product 95140 was offered as a 50% Retinyl Acetate in peanut oil. However, neither product is sterile or tested for in vitro or in vivo use. The end user would have to consider sterilization , as well as determine suitability for in vivo use via IP delivery. Please see the following link to review a publication that may be helpful:
Tracking Systemic and Ocular Vitamin A
https://www.mdpi.com/2073-4409/15/2/163
R4632
Retinyl acetate
synthetic, crystalline solid or supercooled liquid
Synonym(s):
Retinol acetate, Vitamin A acetate
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About This Item
Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
Molecular Weight:
328.49
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058009
UNSPSC Code:
12352205
EC Number:
204-844-2
MDL number:
Beilstein/REAXYS Number:
1915439
Pricing and availability is not currently available.
biological source
synthetic
Quality Segment
assay
≥90% (HPLC)
form
crystalline solid or supercooled liquid
potency
2,600,000-2,940,000 I.U. per g
color
light yellow to dark yellow
mp
57-58 °C, ~58 °C (lit.)
storage temp.
−20°C
SMILES string
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1
InChI
1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
InChI key
QGNJRVVDBSJHIZ-QHLGVNSISA-N
General description
Vitamin A usually occurs in food as retinyl esters, which are the pre-formed sources of vitamin A. Retinyl acetate exists as yellow crystals and is insoluble in water. It is soluble in ethanol and oils.
Application
Retinyl acetate has been used:
- to study its effects on cochlear development in mice
- as a component of an internal standard to quantify antioxidants in yolk
- as an internal standard to determine serum retinol concentration
Biochem/physiol Actions
Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.
Physical form
Packaged as a melt and may exist as a crystalline solid or a supercooled viscous liquid
Analysis Note
Activity based on HPLC comparison to USP standard.
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This Item | |||
|---|---|---|---|
| description synthetic, crystalline solid or supercooled liquid | description synthetic, matrix dispersion, 475,000-650,000 USP units/g | description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard, solution of retinyl acetate (vitamin A) in peanut oil |
| biological source synthetic | biological source synthetic | biological source - | biological source - |
| assay ≥90% (HPLC) | assay - | assay - | assay - |
| form crystalline solid or supercooled liquid | form matrix dispersion | form - | form solution |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level - |
| color light yellow to dark yellow | color yellow | color - | color - |
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signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 4 - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Can I reconstitute this product in oils? And it is safe to administer to animals intraperitoneally by injection?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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