SML0150

Tolcapone

≥98% (HPLC), Catechol-O-methyltransferase inhibitor, powder

• Synonym(s): 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592
• Empirical Formula (Hill Notation): C₁₄H₁₁NO₅
• CAS Number: 134308-13-7
• Molecular Weight: 273.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825198
• NACRES: NA.77
• MDL number: MFCD00866569
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Tolcapone, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow
• solubility: DMSO: ≥15 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
• InChI: 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
• InChI key: MIQPIUSUKVNLNT-UHFFFAOYSA-N
• Gene Information: human ... COMT(1312)

Description

Application

Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.

Biochem/physiol Actions

Orally active catechol-O-methyltransferase (COMT) inhibitor: inhibits both central and peripheral COMT.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Inhibition of catechol-O-methyltransferase by tolcapone increases the half-life and bioavailabilty of levodopa. It therefore is an effective adjunctive therapy in patients with Parkinson′s disease with motor response fluctuations.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Codes: H400
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable