Unfortunately, solution stability studies of this product have not been performed. However, other sources state that this chemical is stable when stored at -20°C for up to 3 months. Avoid repeated freeze/thaw cycles.
Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/132/566/t4680pis.pdf
T4680
Terazosin hydrochloride
≥98% (TLC), α1-adrenoceptor antagonist, powder
Synonym(s):
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Check Cart for Availability | $241.00 |
250 mg | Available to ship TODAY | $1,050.00 $892.50 |
About This Item
Empirical Formula (Hill Notation):
C19H25N5O4 · HCl
CAS Number:
Molecular Weight:
423.89
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
eCl@ss:
32150313
Assay:
≥98% (TLC)
Form:
powder
Product Name
Terazosin hydrochloride, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow, methanol: 20 mg/mL, clear, colorless, ethanol: 4 mg/mL
originator
Abbott
SMILES string
Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
InChI
1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChI key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
General description
Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.
Application
Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.
Biochem/physiol Actions
α1-adrenoceptor antagonist.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.
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This Item | |||
|---|---|---|---|
| description ≥98% (TLC), powder | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard | description - |
| assay ≥98% (TLC) | assay - | assay - | assay - |
| form powder | form - | form - | form - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| solubility H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow, ethanol: 4 mg/mL, methanol: 20 mg/mL, clear, colorless | solubility - | solubility - | solubility - |
| color white to off-white | color - | color - | color - |
| originator Abbott | originator - | originator - | originator - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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Can this product be frozen in saline solution and thawed for later use? For how long is the product stable in solution or should it be made fresh prior to use?
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