T7205

Tegafur

powder

• Synonym(s): 5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur
• Empirical Formula (Hill Notation): C₈H₉FN₂O₃
• CAS Number: 17902-23-7
• Molecular Weight: 200.17
• NACRES: NA.77
• PubChem Substance ID: 329826861
• UNSPSC Code: 12352200
• EC Number: 241-846-2
• MDL number: MFCD00012351
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• mp: 171-173 °C (lit.)
• solubility: DMSO: >50 mg/mL
• storage temp.: room temp
• SMILES string: FC1=CN(C2CCCO2)C(=O)NC1=O
• InChI: 1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
• InChI key: WFWLQNSHRPWKFK-UHFFFAOYSA-N

Description

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT).

Biochem/physiol Actions

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Preparation Note

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable