FKBP1A
FK506 binding protein 1A, 12kDa
Synonyme:
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE
Spezies:
Human FKBP1A (2280), Mouse Fkbp1a (14225), Rat Fkbp1a (25639), domestic guinea pig Fkbp1a (100713967), chicken FKBP1A (374233), Domestic Rabbit FKBP1A (100328942), sheep FKBP1A (101105938), cow FKBP1A (614795), domestic cat FKBP1A (101100379), naked mole-rat Fkbp1a (101702830)
UniProtKB-ID:
Gen-ID:
- Human(2280) Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
- Mouse(14225) FK506 binding protein 1a
- Rat(25639) FK506 binding protein 1a
- domestic guinea pig(100713967) FK506 binding protein 1A, 12kDa
- chicken(374233) FK506 binding protein 1A, 12kDa
- Domestic Rabbit(100328942) FK506 binding protein 1A, 12kDa
- sheep(101105938) FK506 binding protein 1A, 12kDa
- cow(614795) FK506 binding protein 1A, 12kDa
- domestic cat(101100379) FK506 binding protein 1A, 12kDa
- naked mole-rat(101702830) FK506 binding protein 1A, 12kDa
- dog(100686033) FK506 binding protein 1A, 12kDa
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-FKBP1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-FKBP12 antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
ANTI-FKBP12 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Produktnummer
Beschreibung
Spezies
Sirolimus -Lösung, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human