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Merck

NR1H4

nuclear receptor subfamily 1, group H, member 4

Synonymes:
BAR, FXR, HRR-1, HRR1, RIP14
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(9971) Summary: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(20186) nuclear receptor subfamily 1, group H, member 4
  • Rat(60351) nuclear receptor subfamily 1, group H, member 4
  • domestic cat(101096997) nuclear receptor subfamily 1, group H, member 4
  • naked mole-rat(101714263) nuclear receptor subfamily 1, group H, member 4
  • cow(540528) nuclear receptor subfamily 1, group H, member 4
  • domestic guinea pig(100734377) nuclear receptor subfamily 1, group H, member 4
  • Zebrafish(436847) nuclear receptor subfamily 1, group H, member 4
  • Horse(100052821) nuclear receptor subfamily 1, group H, member 4
  • chicken(373902) nuclear receptor subfamily 1, group H, member 4
  • dog(612928) nuclear receptor subfamily 1, group H, member 4
  • sheep(101105401) nuclear receptor subfamily 1, group H, member 4
  • Domestic Rabbit(100009485) nuclear receptor subfamily 1, group H, member 4

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
Ursodeoxycholic acid, ≥99%,
Espèce(s)
human
Ursodiol, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Chenodeoxycholic acid, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Ursodeoxycholic acid impurity standard, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
Ursodeoxycholic acid, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-NR1H4 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-NR1H4, (C-terminal) antibody produced in mouse, clone 1B10, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-NR1H4 antibody produced in mouse, clone 1G11, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence

western blot

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human NR1H4,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Nr1h4,
Espèce(s)
mouse