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711489

1-Hydroxybenzotriazole hydrate

wetted with not less than 20 wt. % water, 97% dry basis

Synonym(s):

HOBt Hydrate

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Size/SKUAvailabilityPrice
50 g
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$153.00
250 g
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$516.00
1 kg
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$1,600.00

About This Item

Empirical Formula (Hill Notation):
C6H5N3O · xH2O
CAS Number:
Molecular Weight:
135.12 (anhydrous basis)
PubChem Substance ID:
UNSPSC Code:
12352000
MDL number:
NACRES:
NA.22
EC Number:
219-989-7
Beilstein/REAXYS Number:
4515
Assay:
97% dry basis
Form:
powder

$153.00


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Quality Segment

assay

97% dry basis

form

powder

quality

wetted with not less than 20 wt. % water

composition

Water content, ~20%

reaction suitability

reaction type: Addition Reactions

mp

155-158 °C (lit.)

solubility

DMF: 0.1 g/mL, clear

SMILES string

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

InChI key

PJUPKRYGDFTMTM-UHFFFAOYSA-N

General description

1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.

Application

1-Hydroxybenzotriazole hydrate is used as an additive:
  • In the oligonucleotide couplings.
  • In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).
1-Hydroxybenzotriazole hydrate can also be used:
  • In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.

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This Item
157260
description

wetted with not less than 20 wt. % water, 97% dry basis

description

wetted with not less than 14 wt. % water, 98% dry basis

assay

97% dry basis

assay

98% dry basis

Quality Level

200

Quality Level

200

solubility

DMF: 0.1 g/mL, clear

solubility

-

reaction suitability

reaction type: Addition Reactions

reaction suitability

reaction type: Addition Reactions

form

powder

form

solid

mp

155-158 °C (lit.)

mp

155-158 °C (lit.)


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Pictograms

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Signal Word

Danger

Hazard Codes

Hazard Classifications

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

Storage Class

4.1A - Other explosive hazardous materials

WGK

WGK 1

Flash Point (°F)

314.6 °F

Flash Point (°C)

157 °C

PPE (personal protective equipment)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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