901376
Polyester bis-MPA dendron
no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3
Synonym(s):
PFd-G3-BOCNH-Acetylene, bis-MPA dendron
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $673.00 |
About This Item
Empirical Formula (Hill Notation):
C107H135NO53
Molecular Weight:
2283.19
NACRES:
NA.23
UNSPSC Code:
12162002
Quality Segment
form
solid
mol wt
generation 3
no. Surface Groups
8
color
white to off-white
storage temp.
−20°C
General description
- Polymer architecture: Dendron
- Generation: 3
- Core functional group: Boc-protected amine
- End Group Functionality: Alkyne
- No. Surface Groups: 8
- Calculated Mol. Wt.: 2283.21 g/mol
- Boc : tert-Butyloxycarbonyl
- bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.
Application
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.
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This Item | |||
|---|---|---|---|
| description no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3 | description 16 acetylene, 1 NHBoc (core), generation 4 | description no. Surface Groups 4, NHBoc, 1 Biotin (core), generation 2 | description generation 2, no. Surface Groups 4 |
| form solid | form solid | form solid (Viscous) | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt generation 3 | mol wt - | mol wt generation 2 | mol wt - |
| color white to off-white | color white to off-white | color colorless to white | color - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| no. Surface Groups 8 | no. Surface Groups - | no. Surface Groups 4 | no. Surface Groups - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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