361550
BIO
≥97% (HPLC), solid, GSK-3GSK-3α/β inhibitor, Calbiochem
Synonym(s):
GSK-3 Inhibitor IX, BIO, (2ʹ Z,3ʹ E)-6-Bromoindirubin-3ʹ-oxime, BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Check Cart for Availability | $175.00 |
10 mg | Check Cart for Availability | $567.00 |
30 mg | Check Cart for Availability | $1,440.00 |
About This Item
$175.00
Product Name
GSK-3 Inhibitor IX, BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
purple
solubility
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
InChI
1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChI key
WFRDXNRAUPBBTO-SQFISAMPSA-N
General description
Application
- in aortic valve interstitial cells (VICs) culture to induce osteogenesis in VICs
- to treat VICs to study its effects on RUNX2, GSK-3β, and p-SMAD protein expression
- and a Wnt pathway activator to study the effect of Wnt and bone morphogenetic protein (BMP) pathways on Saos-2 using differentiation markers Dlx5, Runx2 and Msx2
Biochem/physiol Actions
Packaging
Legal Information
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells. | description The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. | description An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). | description A cell-permeable inhibtor of protein kinase C (IC50 = 20-50 µM). |
| form solid | form solid | form oil | form solid |
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (TLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light | storage condition protect from light, OK to freeze | storage condition OK to freeze |
![[6]-Gingerol, Zingiber officinale An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).](/deepweb/assets/sigmaaldrich/product/images/140/919/0846df46-0b67-4c28-b99d-87e177be65b2/640/0846df46-0b67-4c28-b99d-87e177be65b2.jpg)
Still not finding the right product?
Explore all of our products under GSK-3 Inhibitor IX
Storage Class
11 - Combustible Solids
wgk
WGK 3
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.