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BP1115

Bicalutamide

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

Bicalutamide (CDX), Casodex, Cosudex, N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

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Size/SKUAvailabilityPrice
100 mg
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$265.00

About This Item

Empirical Formula (Hill Notation):
C18H14F4N2O4S
CAS Number:
90357-06-5
Molecular Weight:
430.37
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00869971

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grade

pharmaceutical primary standard

API family

bicalutamide

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F

InChI

1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)

InChI key

LKJPYSCBVHEWIU-UHFFFAOYSA-N

Gene Information

human ... AR(367)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Bicalutamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Bicalutamide Tablets

    • Biochem/physiol Actions

    Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) Antagonist and a pure antiandrogen.
    Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

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    		1071202Y0001444PHR1678
    Bicalutamide British Pharmacopoeia (BP) Reference Standard

    BP1115

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    Bicalutamide United States Pharmacopeia (USP) Reference Standard

    USP

    1071202

    Bicalutamide

    Bicalutamide European Pharmacopoeia (EP) Reference Standard

    Y0001444

    Bicalutamide

    Bicalutamide Pharmaceutical Secondary Standard; Certified Reference Material

    Supelco

    PHR1678

    Bicalutamide

    description

    British Pharmacopoeia (BP) Reference Standard

    description

    United States Pharmacopeia (USP) Reference Standard

    description

    European Pharmacopoeia (EP) Reference Standard

    description

    Pharmaceutical Secondary Standard; Certified Reference Material

    grade

    pharmaceutical primary standard

    grade

    pharmaceutical primary standard

    grade

    pharmaceutical primary standard

    grade

    pharmaceutical secondary standard, certified reference material

    manufacturer/tradename

    BP

    manufacturer/tradename

    USP

    manufacturer/tradename

    EDQM

    manufacturer/tradename

    -

    shelf life

    limited shelf life, expiry date on the label

    shelf life

    -

    shelf life

    -

    shelf life

    -

    format

    neat

    format

    neat

    format

    neat

    format

    neat

    form

    solid

    form

    -

    form

    -

    form

    -

    application(s)

    pharmaceutical
    pharmaceutical small molecule

    application(s)

    pharmaceutical (small molecule)

    application(s)

    pharmaceutical (small molecule)

    application(s)

    pharmaceutical (small molecule)

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    pictograms

    Health hazardEnvironment
    GHS08,GHS09

    signalword

    Danger

    Hazard Classifications

    Aquatic Chronic 1 - Carc. 2 - Repr. 1B

    Storage Class

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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