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I8904

Insulin-like Growth Factor-II from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

IGF-II

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50 μg
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$360.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00241895
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
~7.4 kDa
Impurities:
<1.0EUper1mg (LAL test)

$360.00

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Product Name

Insulin-like Growth Factor-II from mouse, IGF-II, recombinant, expressed in E. coli, lyophilized powder

biological source

mouse

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

quality

endotoxin tested

mol wt

~7.4 kDa

packaging

pkg of 5X50 μg, pkg of 50 μg

impurities

<1.0EUper1mg (LAL test)

UniProt accession no.

storage temp.

−20°C

Gene Information

General description

Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.

Biochem/physiol Actions

Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.

Analysis Note

The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.

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Fibroblast Growth Factor-18 human

description

IGF-II, recombinant, expressed in E. coli, lyophilized powder

description

IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

description

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

biological source

mouse

biological source

human

biological source

mouse

biological source

human

assay

>97% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

>97% (SDS-PAGE)

assay

>95% (SDS-PAGE and HPLC)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Gene Information

mouse ... IGF2(16002), Igf2(16002)

Gene Information

-

Gene Information

mouse ... Fgf8(14179)

Gene Information

human ... FGF18(8817)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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