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M105

Methoctramine hydrate

≥97% (NMR), muscarinic receptor 2 antogonist, solid

Synonym(s):

Methoctramine tetrahydrochloride hydrate, N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$267.00
25 mg

Available to ship TODAYfromMILWAUKEE

$489.00
100 mg

Available to ship TODAYfromMILWAUKEE

$1,660.00
$1,411.00

About This Item

Empirical Formula (Hill Notation):
C36H62N4O2 · 4HCl · xH2O
CAS Number:
Molecular Weight:
728.75 (anhydrous basis)
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.32
MDL number:

$267.00


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Product Name

Methoctramine hydrate, ≥97% (NMR), solid

Quality Segment

assay

≥97% (NMR)

form

solid

color

white

solubility

H2O: >20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Cl.Cl.Cl.COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2OC.COc3ccccc3CNCCCCCCNCCCCCCCCNCCCCCCNCc4ccccc4OC

InChI

1S/2C36H62N4O2.4ClH.H2O/c2*1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;;/h2*11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H;1H2

InChI key

XIIINYPADNNZHA-UHFFFAOYSA-N

Gene Information

human ... CHRM2(1129)

General description

Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.

Application

Methoctramine hydrate has been used:
  • As a muscarinic receptor 2 antogonist.
  • As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.

Biochem/physiol Actions

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.
Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.

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This Item
85610S2876B2417
description

≥97% (NMR), solid

description

≥99.0% (AT), powder or crystals

description

powder or crystals

description

≥98% (HPLC)

assay

≥97% (NMR)

assay

≥99.0% (AT)

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

100

form

solid

form

powder or crystals

form

powder or crystals

form

solid

Gene Information

human ... CHRM2(1129)

Gene Information

-

Gene Information

human ... GRIN1(2902)

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

solubility

H2O: >20 mg/mL

solubility

H2O: 0.1 g/mL, clear

solubility

water, high purity: 100 mg/ml

solubility

DMSO: >20 mg/mL, methanol: 10 mg/mL


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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