MSQC10
SILu™MAb Mouse Stable-Isotope Labeled Monoclonal Antibody
from mouse, recombinant, expressed in CHO cells
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Check Cart for Availability | $451.00 |
About This Item
NACRES:
NA.12
UNSPSC Code:
12352202
Technique(s):
protein mass spectrometry: suitable
Species reactivity:
-
Application:
protein mass spectrometry
Citations:
-
biological source
mouse
Quality Segment
recombinant
expressed in CHO cells
antibody product type
primary antibodies
assay
≥90% (SDS-PAGE)
packaging
vial of 100 μg
technique(s)
protein mass spectrometry: suitable
shipped in
wet ice
storage temp.
−20°C
General description
SILu™MAb Mouse is a recombinant, stable isotope-labeled, mouse monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, SILu™MAb Mouse is designed to be used as a universal internal standard for bioanalysis of monoclonal murine antibodies in animal pharmacokinetics (PK) studies.
SILu™MAb Mouse is an IgG1 antibody with a kappa light chain. Because of overlap with common sequences in the Fc region with candidate murine antibodies, SILu™MAb Mouse provides universal utility, and thus, eliminates the need to produce candidate-specific internal standards.
SILu™MAb Mouse is an IgG1 antibody with a kappa light chain. Because of overlap with common sequences in the Fc region with candidate murine antibodies, SILu™MAb Mouse provides universal utility, and thus, eliminates the need to produce candidate-specific internal standards.
Physical form
Each vial of SILu™MAb Mouse contains the labeled antibody lyophilized from a solution of phosphate buffered saline. Vial content was determined by measuring A280 and using an extinction coefficient (E0.1%) of 1.4.
Preparation Note
Produced utilizing enriched media containing stable isotope labeled amino acids such as [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, SILuMAb Mouse is designed to be used as a universal internal standard for bioanalysis of monoclonal murine antibodies in animal pharmacokinetics (PK) studies
SILu™MAb Mouse recovery is maximized when 0.1% formic acid is used for reconstitution of the lyophilized product.
Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.
Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.
- Briefly centrifuge the vial at ~10,000 × g to collect the product at the bottom of the vial.
- Add 500 μL of ultrapure water containing 0.1% formic acid to the vial.
- Mix the contents by gently inverting the vial a minimum of 5 times.
- Allow the vial to stand at room temperature for at least 15 minutes and repeat mixing by inversion.
Legal Information
SILu is a trademark of Sigma-Aldrich Co. LLC
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This Item | |||
|---|---|---|---|
| description from mouse, recombinant, expressed in CHO cells | description - | description recombinant, expressed in CHO cells | description recombinant, expressed in CHO cells |
| biological source mouse | biological source - | biological source - | biological source - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| packaging vial of 100 μg | packaging vial of 100 μg | packaging - | packaging vial of 100 μg |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥90% (HPLC) | assay ≥90% (SDS-PAGE) |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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