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SAE0066

Adenylyl Cyclase Toxin from Bordetella pertussis

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50 μg
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$667.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352200
Specific activity:
≥ 50  units/mg protein
Assay:
≥70%
Biological source:
Bordetella pertussis Tohama I

$667.00

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biological source

Bordetella pertussis Tohama I

Quality Segment

assay

≥70%

form

liquid

specific activity

≥ 50  units/mg protein

technique(s)

cell culture | mammalian: suitable

suitability

suitable for molecular biology

application(s)

detection

storage temp.

−20°C

Gene Information

Bordetella pertussis Tohama I ... CyaA(69600712)

General description

Research area: IMMUNO AND CKS

Adenylate Cyclase Toxin (ACT or CyaA) is a member of the extensive family of toxins known as Repeat in Toxin (RTX), which are produced by Gram-negative organisms. ACT is encoded by the cyaA gene and secreted extracellularly in the form of a soluble protein. It exhibits both adenylate cyclase enzymatic activity and hemolytic activity. The synthesis, maturation, and secretion of ACT are regulated by the CyaCABD operon. Moreover, its specific cellular receptor, CD11b/CD18 integrin (αMβ2, Mac-1, or CR3), is expressed on myeloid phagocytes.

Application

Adenylyl Cyclase Toxin from Bordetella pertussis has been used as Gα(i/o) inhibitor to study the involvement of the sphingosine 1-phosphate receptor 2/Gα(12/13)/MAPK signaling pathway in the priming and activation of NLRP3 inflammasome during cholestatic liver injury.

Biochem/physiol Actions

Adenylate Cyclase Toxin (CyaA) is responsible for inhibiting the phagocytic activities of neutrophils and macrophages by impairing oxidative response and chemotaxis, ultimately leading to cell apoptosis or necrosis. Additionally, ACT can upregulate the expression of MHC class II and costimulatory molecules on dendritic cells, thereby reducing proinflammatory cytokine production.

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This Item
P2980516561F5551
Adenylyl Cyclase Toxin from Bordetella pertussis

Sigma-Aldrich

SAE0066

Adenylyl Cyclase Toxin from Bordetella pertussis

Pertussis toxin from Bordetella pertussis buffered aqueous glycerol solution

Sigma-Aldrich

P2980

Pertussis toxin from Bordetella pertussis

Pertussis Toxin, Bordetella pertussis, Glycerol Solution Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

Sigma-Aldrich

516561

Pertussis Toxin, Bordetella pertussis, Glycerol Solution

Hemagglutinin, Filamentous from Bordetella pertussis lyophilized powder

Sigma-Aldrich

F5551

Hemagglutinin, Filamentous from Bordetella pertussis

description

-

description

buffered aqueous glycerol solution

description

Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

description

lyophilized powder

assay

≥70%

assay

-

assay

-

assay

-

Gene Information

Bordetella pertussis Tohama I ... CyaA(69600712)

Gene Information

Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)

Gene Information

-

Gene Information

-

biological source

Bordetella pertussis Tohama I

biological source

-

biological source

-

biological source

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

specific activity

≥ 50  units/mg protein

specific activity

-

specific activity

-

specific activity

-

suitability

suitable for molecular biology

suitability

-

suitability

-

suitability

-

Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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