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SML1689
Eupatilin
from (Isolated from Artemisia sp.), ≥98% (HPLC), powder, lipophilic flavonoid
Synonym(s):
2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone, NSC 122413
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About This Item
Empirical Formula (Hill Notation):
C18H16O7
CAS Number:
Molecular Weight:
344.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light
Pricing and availability is not currently available.
Product Name
Eupatilin, ≥98% (HPLC)
biological source
(Isolated from Artemisia sp.)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31
InChI
1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3
InChI key
DRRWBCNQOKKKOL-UHFFFAOYSA-N
Application
Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.
Biochem/physiol Actions
Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.
Flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties
Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601.[1] It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers.[1] Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description phyproof® Reference Substance | description phyproof® Reference Substance | description ≥97% (HPLC) |
| form powder | form - | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95.0% (HPLC) | assay ≥90.0% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. - | storage temp. - | storage temp. room temp |
| solubility DMSO: 20 mg/mL, clear | solubility - | solubility - | solubility DMSO: >10 mg/mL |
| storage condition desiccated, protect from light | storage condition - | storage condition - | storage condition - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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