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SML2356

A939572

≥98% (HPLC)

Synonym(s):

4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide, 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide, A 939572, A939

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Size/SKUAvailabilityPrice
5 mg

Available to ship onSeptember 29, 2026fromMILWAUKEE

$95.20
$80.92
25 mg

Available to ship onSeptember 29, 2026fromMILWAUKEE

$368.00

About This Item

Empirical Formula (Hill Notation):
C20H22ClN3O3
CAS Number:
Molecular Weight:
387.86
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$80.92

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1c(cccc1)OC2CCN(CC2)C(=O)Nc3cc(ccc3)C(=O)NC

InChI

1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)

InChI key

DPYTYQFYDLYWHZ-UHFFFAOYSA-N

Biochem/physiol Actions

A939572 is an orally available piperidine-aryl urea-based small molecule that inhibits stearoyl-CoA desaturase 1 (SCD1) with high potency (IC50 = 37 nM/hSCD1 and <4 nM/mSCD1) with little hERG channel blockade activity (IC50 >100 μM). When administered in ob/ob mice, A939572 effectively reduces desaturation indices in vivo (18:0/18:1n9 ratio from 26.9 to 8.47 in liver; from 15.4 to 7.35 in plasma post 5-day 10 mg/kg bid p.o.). A939572 is a useful tool for probing SCD1-mediated physiological and pathological processes both in cultures (50 nM-10 μM) and in vivo (5-10 mg/kg i.p. or 10 mg/kg p.o. in mice).
Orally available, potent and selective stearoyl-CoA-desaturase 1 (SCD1) inhibitor.

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This Item
569406EMU023031
description

≥98% (HPLC)

description

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).

description

targeting mouse Scd1

form

powder

form

powder

form

lyophilized powder

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL

solubility

-

color

white to beige

color

off-white

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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