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MilliporeSigma

201014

N-Benzylbenzamide

≥98%

Synonym(s):

Benzoic acid benzylamide, N-(Phenylmethyl)benzamide, N-Benzoylbenzylamine

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5 G

$64.40

$64.40


Estimated to ship onDecember 29, 2025Details


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About This Item

Linear Formula:
C6H5CONHCH2C6H5
CAS Number:
Molecular Weight:
211.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
216-063-4
MDL number:

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Product Name

N-Benzylbenzamide, ≥98%

InChI key

LKQUCICFTHBFAL-UHFFFAOYSA-N

InChI

1S/C14H13NO/c16-14(13-9-5-2-6-10-13)15-11-12-7-3-1-4-8-12/h1-10H,11H2,(H,15,16)

SMILES string

O=C(NCc1ccccc1)c2ccccc2

assay

≥98%

mp

104-106 °C (lit.)

solubility

acetone: 25 mg/mL, clear, colorless

functional group

amide
phenyl

Quality Level

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This Item
436798387649N8638
assay

≥98%

assay

98%

assay

99.5%

assay

≥98% (TLC)

solubility

acetone: 25 mg/mL, clear, colorless

solubility

-

solubility

water: soluble 4.01 g/L at 20 °C

solubility

DMSO: 9.80-10.20 mg/mL, clear to slightly hazy, colorless to yellow

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

mp

104-106 °C (lit.)

mp

>300 °C (dec.) (lit.)

mp

<−50 °C (lit.)

mp

-

functional group

amide

functional group

amide, phenyl

functional group

amine

functional group

-

Application

A convenient precursor to α-substituted benzylamines and an indicator for the titration of butyllithium and other lithium bases. For references see Aldrichimica Acta .[1]

General description

N-Benzylbenzamide inhibits the activity of tyrosinase[2].

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yae Eun Chong et al.
Biomedical chromatography : BMC, 33(11), e4653-e4653 (2019-07-20)
Ondansetron, a widely used antiemetic agent, is a P-glycoprotein (P-gp) substrate and therefore expression of P-gp at the blood-brain barrier limits its distribution to the central nervous system (CNS), which was observed to be reversed by coadministration with P-gp inhibitors.
Manting Chiang et al.
Pharmaceutical research, 37(10), 205-205 (2020-09-30)
Modulation of 5-HT3 receptor in the central nervous system (CNS) is a promising approach for treatment of neuropathic pain. The goal was to evaluate the role of P-glycoprotein (Pgp) in limiting exposure of different parts of the CNS to ondansetron
Sung Jin Cho et al.
Bioorganic & medicinal chemistry letters, 16(10), 2682-2684 (2006-03-04)
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited
Aldrichimica Acta, 11, 20-20 (1978)
Zsanett Dorkó et al.
Talanta, 162, 167-173 (2016-11-14)
A simple and efficient method is presented for assessing molecularly imprinted polymers (MIP) and other sorbents from the point of view of practical applications. The adsorption isotherms of the compounds, which need to be separated or detected in an application

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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