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373605

6,6′-Dithiodinicotinic acid

technical grade, 85%

Synonym(s):

Bis[3-Carboxypyridine] 6,6′-disulfide, Bis[3-carboxypyridine] 6,6′-disulfide

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Size/SKUAvailabilityPrice
5 g
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$140.00

About This Item

Empirical Formula (Hill Notation):
C12H8N2O4S2
CAS Number:
Molecular Weight:
308.33
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
239-729-6
MDL number:
Assay:
85%
Form:
solid

$140.00


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grade

technical grade

Quality Segment

assay

85%

form

solid

mp

263-265 °C (lit.)

functional group

carboxylic acid, disulfide

SMILES string

OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1

InChI

1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)

InChI key

GSASOFRDSIKDSN-UHFFFAOYSA-N

General description

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

Application

6,6′-Dithiodinicotinic acid may be employed as:
  • specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
  • modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
  • dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
  • water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
  • chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
  • spectrophotometric determination of thiols and of total glutathione in human blood

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This Item
1211287513881496367
description

technical grade, 85%

description

United States Pharmacopeia (USP) Reference Standard

description

90%

description

98%

assay

85%

assay

-

assay

90%

assay

98%

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

100

mp

263-265 °C (lit.)

mp

>360 °C (lit.)

mp

220-223 °C (lit.)

mp

93-95 °C (lit.)

form

solid

form

-

form

-

form

-

functional group

carboxylic acid, disulfide

functional group

-

functional group

bromo

functional group

-

grade

technical grade

grade

pharmaceutical primary standard

grade

-

grade

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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