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420069

4,5-Dimethoxy-2-nitrobenzyl chloroformate

97%, for peptide synthesis

Synonym(s):

6-Nitroveratryl chloroformate, 6-Nitroveratryloxycarbonyl chloride, NVOC chloride, NVOC-Cl

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Size/SKUAvailabilityPrice
1 g

Available to ship TODAYfromMILWAUKEE

$256.00

About This Item

Linear Formula:
ClCO2CH2C6H2(OCH3)2NO2
CAS Number:
Molecular Weight:
275.64
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Beilstein/REAXYS Number:
2389168

$256.00


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Product Name

4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%

Quality Segment

assay

97%

form

powder

reaction suitability

reactivity: alcohol reactive, reactivity: amine reactive, reagent type: protection reagent

mp

125 °C (dec.) (lit.)

application(s)

peptide synthesis

functional group

chloro, nitro

storage temp.

2-8°C

SMILES string

COc1cc(COC(Cl)=O)c(cc1OC)[N+]([O-])=O

InChI

1S/C10H10ClNO6/c1-16-8-3-6(5-18-10(11)13)7(12(14)15)4-9(8)17-2/h3-4H,5H2,1-2H3

InChI key

RWWPKIOWBQFXEE-UHFFFAOYSA-N

Application

4,5-Dimethoxy-2-nitrobenzyl chloroformate (NVOC-Cl) is a photolabile protecting reagent, commonly used in peptide or nucleotide synthesis to protect amines and hydroxyl groups. General applications are:
  • Preparation of inactive, caged protein conjugates which can be activated by irradiating near-ultraviolet light.
  • Solid-phase synthesis of base-sensitive S-acylthioethyl (SATE)-prooligonucleotides.
  • Modification of surface properties by introducing photocleavable NVOC moiety into chitosan to control cell attachment.



Pictograms

Corrosion

Signal Word

Danger

Hazard Codes

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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