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764205

Alkyne-PEG4-maleimide

90% (HPLC)

Synonym(s):

Acetylene-PEG4-maleimide

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$86.20
$90.50
25 mg

Available to ship TODAYfromMILWAUKEE

$178.00

About This Item

Empirical Formula (Hill Notation):
C18H26N2O7
Molecular Weight:
382.41
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
eCl@ss:
32150917
Assay:
90% (HPLC)
Form:
liquid

$90.50

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Quality Segment

assay

90% (HPLC)

form

liquid

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

mp

62-67 °C

functional group

alkyne, maleimide

storage temp.

−20°C

SMILES string

O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O

InChI

1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)

InChI key

GHEBECZRHJXPTL-UHFFFAOYSA-N

Application

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

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This Item
760668764213764167
description

90% (HPLC)

description

for Copper-free Click Chemistry

description

for copper catalyzed click labeling

description

-

assay

90% (HPLC)

assay

-

assay

95%

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent, reaction type: click chemistry

reaction suitability

reaction type: click chemistry

reaction suitability

reagent type: cross-linking reagent, reaction type: click chemistry

mp

62-67 °C

mp

-

mp

55-64 °C

mp

-

form

liquid

form

solid

form

solid

form

liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C


Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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