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925004

E7820-PEG1-NH2 hydrochloride

Synonym(s):

N-(2-(2-Aminoethoxy)ethyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide, Crosslinker−E3 Ligase ligand conjugate hydrochloride, DCAF15 protein degrader building block

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$469.00

About This Item

Empirical Formula (Hill Notation):
C21H23N5O4S · xHCl
Molecular Weight:
441.50 (free base basis)
NACRES:
NA.22
UNSPSC Code:
12352200

$469.00

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ligand

E7820

Quality Segment

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

technique(s)

targeted protein degradation: suitable

functional group

amine

storage temp.

2-8°C

Application

Protein degrader building block E7820-PEG1-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Protein Degrader Building Blocks

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

Other Notes

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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This Item
925012925101925128
E7820-PEG1-NH2 hydrochloride

Sigma-Aldrich

925004

E7820-PEG1-NH2 hydrochloride

E7820-PEG5-NH2 hydrochloride

Sigma-Aldrich

925012

E7820-PEG5-NH2 hydrochloride

E7820-C3-NH2 hydrochloride

Sigma-Aldrich

925101

E7820-C3-NH2 hydrochloride

E7820-C6-NH2 hydrochloride

Sigma-Aldrich

925128

E7820-C6-NH2 hydrochloride

description

-

description

-

description

-

description

-

reaction suitability

reagent type: ligand-linker conjugate, reactivity: carboxyl reactive

reaction suitability

reagent type: ligand-linker conjugate, reactivity: carboxyl reactive

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reagent type: ligand-linker conjugate, reactivity: carboxyl reactive

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

ligand

E7820

ligand

E7820

ligand

E7820

ligand

E7820

functional group

amine

functional group

amine

functional group

amine

functional group

amine

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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