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BTS

Name: BTS
Brand: MM
Price: 206 USD
Availability: InStock

≥95% (HPLC), Ca2+-stimulated myosin S1 ATPase inhibitor, crystalline solid

Synonym(s):

BTS, N-Benzyl- p-toluenesulphonamide, N-Benzyl-p-toluenesulphonamide

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Size/SKU	Availability	Price
5 mg	Check Cart for Availability	$206.00

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₅NO₂S

CAS Number:

1576-37-0

Molecular Weight:

261.34

MDL number:

MFCD00159328

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

crystalline solid

Storage condition:

OK to freeze, protect from light

$206.00

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Properties

Product Name

BTS, A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

Quality Segment

100

description

RTECS - XT5490000

assay

≥95% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCc2ccccc2)c1ccc(cc1)C

InChI

1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3

InChI key

WTHKAJZQYNKTCJ-UHFFFAOYSA-N

Description

General description

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Ca²⁺-stimulated myosin S1 ATPase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	567731	324759	569397
Sigma-Aldrich 203895 BTS	Sigma-Aldrich 567731 Sphingosine Kinase Inhibitor	Sigma-Aldrich 324759 Elastase Inhibitor IV	Sigma-Aldrich 569397 Staurosporine, Streptomyces sp.
description A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.	description The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.	description The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC₅₀ = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).
form crystalline solid	form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥99% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, desiccated (hygroscopic), protect from light	storage condition OK to freeze, protect from light	storage condition protect from light, OK to freeze

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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