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1,2-Dioctanoyl-sn-glycerol

Name: 1,2-Dioctanoyl-<i>sn-</i>glycerol
Brand: MM
Price: 106 USD

Cell-permeable activator of protein kinase C (PKC).

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Synonym(s):

1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV

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Size/SKU	Availability	Price
10 mg	Check Cart for Availability	$106.00

About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₆O₅

CAS Number:

60514-48-9

Molecular Weight:

344.49

MDL number:

MFCD00036835

UNSPSC Code:

12352200

NACRES:

NA.77

Form:

oil

Storage condition:

OK to freeze

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Properties

Quality Segment

100

description

RTECS - RH0764500

form

oil

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

clear colorless

solubility

chloroform: soluble, ethyl acetate: soluble

shipped in

wet ice

storage temp.

−70°C

SMILES string

O([C@H](COC(=O)CCCCCCC)CO)C(=O)CCCCCCC

InChI

1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1

InChI key

ZQBULZYTDGUSSK-KRWDZBQOSA-N

Description

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKC_α than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein kinase C

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Analysis Note

Single spot by TLC

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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1 of 1

This Item	495414
Sigma-Aldrich 317505 1,2-Dioctanoyl-sn-glycerol	Sigma-Aldrich 495414 1-Oleoyl-2-acetyl-sn-glycerol
description Cell-permeable activator of protein kinase C (PKC).	description Cell-permeable diacylglycerol analog that activates Ca²⁺-dependent protein kinase C.
form oil	form oil
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100
storage temp. −70°C	storage temp. −20°C
solubility ethyl acetate: soluble, chloroform: soluble	solubility DMSO: soluble, ethanol: soluble
storage condition OK to freeze	storage condition OK to freeze

Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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