360512
Glycocholic Acid, Sodium Salt
Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.
Synonym(s):
Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
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About This Item
Quality Segment
description
Merck USA index - 14, 4494
assay
100.1% dry basis (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
aggregation number
2.1
color
white to off-white
pKa
3.8
CMC
7.1 mM
solubility
water: 200 mg/mL, ethanol: soluble
shipped in
ambient
storage temp.
15-25°C
SMILES string
[Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C
InChI
1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
InChI key
OABYVIYXWMZFFJ-UHFFFAOYSA-M
General description
Application
- as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
- in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
- to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K1) to analyze its influence on the quality and stability of the mixed micelle systems
Biochem/physiol Actions
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This Item | |||
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| description Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1. | description Induces apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. Aggregation number: 2. | description Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins. | description Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A. |
| form solid | form solid | form solid | form solid |
| assay 100.1% dry basis (titration) | assay ≥96% (TLC) | assay ≥97% (TLC) | assay ≥98% (TLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 15-25°C | storage temp. 15-25°C | storage temp. 15-25°C | storage temp. −20°C |
| solubility water: 200 mg/mL, ethanol: soluble | solubility water: 10 mg/mL | solubility water: 100 mg/mL | solubility ethanol: 20 mg/mL, DMSO: 20 mg/mL, water: 1 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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